ARAP1 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH), Sterile alpha motif (SAM) domain containing (SAMD), ArfGAPs, Ankyrin repeat domain containing (ANKRD)
Name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Description	The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARAP1 is a multidomain protein endowed with ADP‐ribosylation factor (Arf) GTPase‐activating protein (GAP) activity as well as Rho GAP functions that modulate diverse cellular processes through regulation of membrane trafficking and cytoskeletal dynamics. For example, in pancreatic islets, genetic and functional studies have implicated increased ARAP1 expression in type 2 diabetes susceptibility, likely by affecting beta‐cell function and insulin secretion (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In other contexts, ARAP1 directly interacts with receptors and signaling proteins to control their intracellular itinerary. ARAP1 associates with the carboxyl terminus of angiotensin II type 1 receptors and promotes their recycling back to the plasma membrane, thereby reestablishing receptor responsiveness after internalization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, ARAP1 is recruited early during epidermal growth factor (EGF) stimulation where it localizes to Rab5-positive endocytic structures; its activity delays EGFR progression into classical early endosomes, modulating receptor ubiquitination and degradation while influencing downstream ERK and JNK signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " In breast cancer cells, ARAP1 becomes phosphorylated via its interaction with PTK6, an event that counteracts EGFR down‐regulation and may thereby contribute to sustained signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, ARAP1 plays a role in cytoskeletal remodeling; it is required for the formation of leading edge structures in fibroblast models and contributes to regulation of circular dorsal ruffle architecture through modulation of Arf1/5 activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In the context of oncogenic signaling, ARAP1 associates with partners such as Lrrk1 within BCR–ABL1–containing complexes to potentially influence MAP kinase responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Finally, emerging work reveals that non-coding RNAs (ARAP1-AS1 and ARAP1-AS2) regulate ARAP1 mRNA levels in diabetic conditions, underscoring its potential as a biomarker in diabetes and diabetic nephropathy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and its GAP activity is further modulated by binding to phosphatidylinositol 3,4,5-trisphosphate as well as effector proteins such as GGA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennifer R Kulzer, Michael L Stitzel, Mario A Morken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.12.011"}], "href": "https://doi.org/10.1016/j.ajhg.2013.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24439111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24439111"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "T Nielsen, T Sparsø, N Grarup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-011-2054-3"}], "href": "https://doi.org/10.1007/s00125-011-2054-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21267535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21267535"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yun Qian, Meihua Dong, Feng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2015.02.026"}], "href": "https://doi.org/10.1016/j.mce.2015.02.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25749274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25749274"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Deng-Fu Guo, Isabelle Chenier, Valerie Tardif, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.09.154"}], "href": "https://doi.org/10.1016/j.bbrc.2003.09.154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14559250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14559250"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hye-Young Yoon, Ju-Seog Lee, Paul A Randazzo "}, {"type": "b", "children": [{"type": "t", "text": "ARAP1 regulates endocytosis of EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2008.00839.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2008.00839.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18939958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18939958"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tiziana Daniele, Giuseppe Di Tullio, Michele Santoro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARAP1 regulates EGF receptor trafficking and signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2008.00823.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2008.00823.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18764928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18764928"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fanny Campa, Hye-Young Yoon, Vi Luan Ha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.028266"}], "href": "https://doi.org/10.1074/jbc.M109.028266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19666464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19666464"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gulzar Ahmad, Bhopal C Mohapatra, Nancy A Schulte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2014.10.019"}], "href": "https://doi.org/10.1016/j.biocel.2014.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25449262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25449262"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shin-Ae Kang, Eun-Saem Lee, Hye-Young Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.088971"}], "href": "https://doi.org/10.1074/jbc.M109.088971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20554524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20554524"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Muneaki Miyata, Yoshiyuki Rikitake, Motonori Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.016436"}], "href": "https://doi.org/10.1074/jbc.M109.016436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19589776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19589776"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Junya Hasegawa, Kazuya Tsujita, Tadaomi Takenawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-01-0017"}], "href": "https://doi.org/10.1091/mbc.E12-01-0017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22573888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22573888"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "B Titz, T Low, E Komisopoulou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.331"}], "href": "https://doi.org/10.1038/onc.2010.331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20697350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20697350"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ying Yang, Xiaomeng Lv, Qiuling Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of circulating lncRNA expression profiles in patients with diabetes mellitus and diabetic nephropathy: Differential expression profile of circulating lncRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Nephrol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5414/CN109525"}], "href": "https://doi.org/10.5414/CN109525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31079598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31079598"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kerry M Jacques, Zhongzhen Nie, Stacey Stauffer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208875200"}], "href": "https://doi.org/10.1074/jbc.M208875200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12376537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12376537"}]}]}]}
Synonyms	CENTD2
Proteins	ARAP1_HUMAN
NCBI Gene ID	116985
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARAP1 has 7,685 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.

Click the + buttons to view associations for ARAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ARAP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARAP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ARAP1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARAP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARAP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ARAP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ARAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ARAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ARAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ARAP1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for ARAP1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ARAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ARAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.