ARFGEF1 Gene

Name	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Description	ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARFGEF1, which encodes the large Arf guanine nucleotide‐exchange factor BIG1, is an evolutionarily conserved regulator that catalyzes the activation of Arf small GTPases to promote vesicular trafficking and membrane dynamics at the Golgi and endosomal compartments."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In addition to its well‐established role in secretory pathway regulation, ARFGEF1 undergoes dynamic intracellular relocalization – including cAMP/PKA–mediated phosphorylation and subsequent nuclear accumulation – that likely influences additional cellular processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n ARFGEF1 is also emerging as an important modulator in oncogenic contexts. Its expression is controlled by several noncoding RNAs: for example, miR‐27b suppresses ARFGEF1 to restrict anchorage‐independent growth in colon cancer cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while in thyroid and cervical carcinomas, miR–215, miR–133b, and regulatory circular RNAs indirectly modulate ARFGEF1 levels to affect cell proliferation, migration, invasion, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " In osteoblasts, ARFGEF1 is a direct target of miR‐376c, whereby its downregulation contributes to reduced ARF6 activation and impaired canonical Wnt/β–catenin signaling, ultimately inhibiting osteoblast differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, epigenetic silencing through promoter hypermethylation has been reported in breast cancer, suggesting that loss of ARFGEF1 expression may also have tumor–suppressive implications in certain contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the nervous system, ARFGEF1 is critical for proper neurite outgrowth, neuronal polarization, and cortical development. Haploinsufficiency or pathogenic variants lead to defects in deep–layer neuronal survival, aberrant migration, and misrouting of axonal projections – findings that are associated with developmental delay, epileptic phenotypes, and epileptic encephalopathy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": " Similarly, in microglial cells, modulation of ARFGEF1 levels alters neuroinflammatory responses and migration through effects on the PI3K/Akt/NF–κB signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond mammalian cells, homologs of ARFGEF1 (BIG1) in pathogenic fungi such as Candida albicans are required for proper beta–1,6–glucan synthesis, filamentation, and virulence, underscoring the broad biological and clinical significance of ARFGEF1 family proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings reveal that ARFGEF1 exerts multifaceted functions – from orchestrating membrane trafficking and vesicle formation to influencing cell polarity, oncogenic transformation, and neurodevelopmental as well as inflammatory processes. Disruption of ARFGEF1 function has profound consequences across diverse biological systems, emphasizing its potential as a candidate for therapeutic targeting in both cancer and neurological disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Barbara Mouratou, Valerie Biou, Alexandra Joubert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-6-20"}], "href": "https://doi.org/10.1186/1471-2164-6-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15717927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15717927"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John Wright, Richard A Kahn, Elizabeth Sztul "}, {"type": "b", "children": [{"type": "t", "text": "Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-014-1602-7"}], "href": "https://doi.org/10.1007/s00018-014-1602-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24728583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24728583"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Philip Ian Padilla, Gustavo Pacheco-Rodriguez, Joel Moss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0307345101"}], "href": "https://doi.org/10.1073/pnas.0307345101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14973189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14973189"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fuminobu Kuroda, Joel Moss, Martha Vaughan "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0611696104"}], "href": "https://doi.org/10.1073/pnas.0611696104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17360629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17360629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carmen Citterio, Heather D Jones, Gustavo Pacheco-Rodriguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0510571103"}], "href": "https://doi.org/10.1073/pnas.0510571103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16467138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16467138"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rei Matsuyama, Daisuke Okuzaki, Masato Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12834"}], "href": "https://doi.org/10.1111/cas.12834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26473412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26473412"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jihua Han, Meiyin Zhang, Chunlei Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1444-1"}], "href": "https://doi.org/10.1038/s41419-019-1444-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30814512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30814512"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Z Li, J Xu, H Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol Invest (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40618-021-01713-2"}], "href": "https://doi.org/10.1007/s40618-021-01713-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34854069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34854069"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lingling Jiang, Xuexin Wang "}, {"type": "b", "children": [{"type": "t", "text": "The miR-133b/brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) axis represses proliferation, invasion, and migration in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2027063"}], "href": "https://doi.org/10.1080/21655979.2022.2027063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35048795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35048795"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jyoti Kureel, Aijaz A John, Ravi Prakash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR 376c inhibits osteoblastogenesis by targeting Wnt3 and ARF-GEF-1 -facilitated augmentation of beta-catenin transactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26490"}], "href": "https://doi.org/10.1002/jcb.26490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29125885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29125885"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ju Hee Kim, Tae Woo Kim, Sun Jung Kim "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/bmbrep.2011.44.8.523"}], "href": "https://doi.org/10.5483/bmbrep.2011.44.8.523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21871176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21871176"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lőrinc Pongor, Máté Kormos, Christos Hatzis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13073-015-0228-1"}], "href": "https://doi.org/10.1186/s13073-015-0228-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26474971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26474971"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "JiaJie Teoh, Narayan Subramanian, Maria Elena Pero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "A"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2019.104632"}], "href": "https://doi.org/10.1016/j.nbd.2019.104632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31678406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31678406"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Quentin Thomas, Thierry Gautier, Dana Marafi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haploinsufficiency of ARFGEF1 is associated with developmental delay, intellectual disability, and epilepsy with variable expressivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41436-021-01218-6"}], "href": "https://doi.org/10.1038/s41436-021-01218-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34113008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34113008"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0175888"}], "href": "https://doi.org/10.1371/journal.pone.0175888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28414797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28414797"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zhijun You, Zhenzhen Yang, Shuang Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2022.01.014"}], "href": "https://doi.org/10.1016/j.neuroscience.2022.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35090882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35090882"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Takashi Umeyama, Aki Kaneko, Hiroshi Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.74.4.2373-2381.2006"}], "href": "https://doi.org/10.1128/IAI.74.4.2373-2381.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16552067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16552067"}]}]}]}
Synonyms	BIG1, ARFGEP1
Proteins	BIG1_HUMAN
NCBI Gene ID	10565
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARFGEF1 has 7,634 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 130 datasets.

Click the + buttons to view associations for ARFGEF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARFGEF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARFGEF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARFGEF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARFGEF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARFGEF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARFGEF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARFGEF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ARFGEF1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARFGEF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARFGEF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARFGEF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARFGEF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARFGEF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARFGEF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ARFGEF1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARFGEF1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARFGEF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARFGEF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARFGEF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARFGEF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ARFGEF1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ARFGEF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARFGEF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARFGEF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARFGEF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ARFGEF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ARFGEF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARFGEF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARFGEF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARFGEF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARFGEF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ARFGEF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ARFGEF1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ARFGEF1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARFGEF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ARFGEF1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARFGEF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARFGEF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARFGEF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARFGEF1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARFGEF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.