ARHGAP11A Gene

HGNC Family	Rho GTPase activating proteins (ARHGAP)
Name	Rho GTPase activating protein 11A
Description	This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARHGAP11A encodes a Rho GTPase‐activating protein that plays multifaceted roles in both neurodevelopment and tumor biology. It was originally characterized as the ancestral gene for the partially duplicated ARHGAP11B, a protein implicated in human neocortical expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer contexts, ARHGAP11A has been reported to drive cell cycle progression and proliferation. In basal‐like breast cancer cells, for instance, high expression of ARHGAP11A supports proliferation, whereas its knockdown causes a p27‐mediated arrest in the G1 phase."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Conversely, another study demonstrated that the RhoGAP domain of ARHGAP11A can bind to the tetramerization domain of p53, stabilizing its active conformation and enhancing DNA binding, thus promoting cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung adenocarcinoma, ARHGAP11A is markedly overexpressed compared to normal tissue, and its up‐regulation correlates with advanced clinical stage, poor differentiation, lymph node metastasis, and reduced overall survival, identifying it as an independent prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in gastric cancer the protein is up‐regulated and functionally promotes malignant progression by enhancing cell proliferation, migration, and invasion; mechanistic studies suggest that ARHGAP11A interacts with tropomyosin 1 (TPM1) to affect actin filament stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, dysregulation of ARHGAP11A is implicated in non–small cell lung cancer and hepatocellular carcinoma via competing endogenous RNA networks. In these settings, aberrant levels of specific long non‐coding RNAs and microRNAs (for example, miR-525-5p and miR-19a) lead to altered ARHGAP11A expression that in turn promotes tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, ARHGAP11A emerges as an important regulator of RhoA signaling and cell cycle processes whose context-dependent actions—ranging from oncogenic promotion of proliferation and metastasis to activation of p53-mediated cell-cycle arrest—highlight its potential as both a prognostic biomarker and a therapeutic target across multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marta Florio, Mareike Albert, Elena Taverna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaa1975"}], "href": "https://doi.org/10.1126/science.aaa1975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25721503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25721503"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Campbell D Lawson, Cheng Fan, Natalia Mitin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2923"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27216196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27216196"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Xu, Xiaolin Zhou, Jilin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2013.04.017"}], "href": "https://doi.org/10.1016/j.celrep.2013.04.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23684608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23684608"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bingwen Yan, Mingwei Han, Rongrong Liu "}, {"type": "b", "children": [{"type": "t", "text": "[Rho GTPase-activating protein 11A (ARHGAP11A) is up-regulated in lung adenocarcinoma and positively associated with poor prognosis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34140070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34140070"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shuchen Chen, He Duan, Yusai Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and prognostic analysis of Rho GTPase-activating protein 11A in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/atm-21-2113"}], "href": "https://doi.org/10.21037/atm-21-2113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34164506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34164506"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoying Guan, Xiaoli Guan, Junjie Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGAP11A Promotes the Malignant Progression of Gastric Cancer by Regulating the Stability of Actin Filaments through TPM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/4146910"}], "href": "https://doi.org/10.1155/2021/4146910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34912455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34912455"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bin Zhang, Zhou Jin, Hao Zhang "}, {"type": "b", "children": [{"type": "t", "text": "LINC01207 promotes the progression of non-small cell lung cancer via regulating ARHGAP11A by sponging miR-525-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-203197"}], "href": "https://doi.org/10.3233/CBM-203197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34487020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34487020"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shan Lu, Jiansheng Zhou, Yimin Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0676-x"}], "href": "https://doi.org/10.1186/s12943-017-0676-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28724429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28724429"}]}]}]}
Synonyms	GAP (1-12)
Proteins	RHGBA_HUMAN
NCBI Gene ID	9824
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARHGAP11A has 6,096 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for ARHGAP11A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARHGAP11A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP11A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARHGAP11A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARHGAP11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARHGAP11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP11A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP11A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP11A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP11A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARHGAP11A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGAP11A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP11A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARHGAP11A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARHGAP11A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP11A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARHGAP11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARHGAP11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARHGAP11A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARHGAP11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARHGAP11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ARHGAP11A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ARHGAP11A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARHGAP11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARHGAP11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARHGAP11A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARHGAP11A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARHGAP11A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ARHGAP11A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARHGAP11A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ARHGAP11A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARHGAP11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARHGAP11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARHGAP11A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARHGAP11A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARHGAP11A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP11A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARHGAP11A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARHGAP11A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP11A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ARHGAP11A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ARHGAP11A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.