ARHGAP19 Gene

HGNC Family	Rho GTPase activating proteins (ARHGAP)
Name	Rho GTPase activating protein 19
Description	Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARHGAP19 is a Rho GTPase‐activating protein that plays diverse roles in cell physiology and development. In epithelial‐derived cancer cells that have undergone epithelial–mesenchymal transition, ARHGAP19 is aberrantly expressed and subject to repression by microRNAs such as miR‑200c and miR‑193a, processes that contribute to reduced cell migration and enhanced sensitivity to apoptotic stimuli."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, studies in murine embryos have shown that naturally occurring allelic variations affecting ARHGAP19 expression are associated with differences in neural tube closure, suggesting an important developmental role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the hematopoietic compartment, ARHGAP19 is expressed in a lineage‐specific manner and functions as a critical regulator of cytokinesis by modulating RhoA activity. Its sequential phosphorylation by ROCK and CDK1 controls its subcellular localization during mitosis, ensuring proper cell elongation and successful abscission, while disruption of these phosphorylation events leads to multinucleation and defective cell division."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, gene structure and expression pattern analyses indicate that ARHGAP19 is predominantly expressed during fetal development, pointing to a role in developmental processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In reproductive biology, increased ARHGAP19 levels in endometrial epithelial cells facilitate cytoskeletal reorganization and the remodeling of junctional proteins, thereby contributing to the transition from a non‐receptive to a receptive state, and similar miRNA‐mediated regulation has been observed to inhibit cell migration in triple‐negative breast cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Erin N Howe, Dawn R Cochrane, Jennifer K Richer "}, {"type": "b", "children": [{"type": "t", "text": "Targets of miR-200c mediate suppression of cell motility and anoikis resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr2867"}], "href": "https://doi.org/10.1186/bcr2867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21501518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21501518"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haruo Nakano, Yoji Yamada, Tatsuya Miyazawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.1896"}], "href": "https://doi.org/10.3892/ijo.2013.1896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23588298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23588298"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Megan K Kooistra, Renee Y M Leduc, Christine E Dawe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00124.2011"}], "href": "https://doi.org/10.1152/physiolgenomics.00124.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22045912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22045912"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Claire Marceaux, Dominique Petit, Jacques Bertoglio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of ARHGAP19 by CDK1 and ROCK regulates its subcellular localization and function during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.208397"}], "href": "https://doi.org/10.1242/jcs.208397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29420299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29420299"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Muriel D David, Dominique Petit, Jacques Bertoglio "}, {"type": "b", "children": [{"type": "t", "text": "The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.135079"}], "href": "https://doi.org/10.1242/jcs.135079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24259668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24259668"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lei Lv, Jian Xu, Shuo Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Seq (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10425170600752965"}], "href": "https://doi.org/10.1080/10425170600752965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17454002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17454002"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jingjie Liang, Kui Li, Kaiyu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00689-7"}], "href": "https://doi.org/10.1186/s12958-020-00689-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33407571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33407571"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Beate Vajen, Luisa Greiwe, Vera Schäffer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-192-5p inhibits migration of triple negative breast cancer cells and directly regulates Rho GTPase activating protein 19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.22982"}], "href": "https://doi.org/10.1002/gcc.22982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34296808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34296808"}]}]}]}
Proteins	RHG19_HUMAN
NCBI Gene ID	84986
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARHGAP19 has 5,898 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for ARHGAP19 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARHGAP19 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP19 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP19 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARHGAP19 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARHGAP19 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARHGAP19 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP19 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP19 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP19 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP19 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGAP19 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP19 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARHGAP19 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP19 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARHGAP19 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARHGAP19 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ARHGAP19 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARHGAP19 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARHGAP19 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARHGAP19 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARHGAP19 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGAP19 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARHGAP19 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARHGAP19 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARHGAP19 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ARHGAP19 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ARHGAP19 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARHGAP19 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARHGAP19 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARHGAP19 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARHGAP19 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARHGAP19 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP19 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARHGAP19 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARHGAP19 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ARHGAP19 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP19 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ARHGAP19 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ARHGAP19 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ARHGAP19 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ARHGAP19 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.