ARHGAP24 Gene

HGNC Family	Rho GTPase activating proteins (ARHGAP), Pleckstrin homology domain containing (PLEKH)
Name	Rho GTPase activating protein 24
Description	This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARHGAP24 is emerging as a critical Rho GTPase‐activating protein that modulates signaling networks governing cell migration, differentiation, and proliferation in multiple tissues. In immune cells, its expression is part of trans‐regulated networks, with specific human leukocyte antigen alleles influencing ARHGAP24 levels in monocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the cardiovascular system, genetic association studies have identified ARHGAP24 as a locus linked to electrocardiographic parameters, suggesting it may contribute to the regulation of cardiac conduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the kidney, ARHGAP24 is up‐regulated during podocyte differentiation and functions to balance Rac1 and RhoA signaling; loss‐of‐function mutations in ARHGAP24 have been linked to focal segmental glomerulosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, ARHGAP24 is a canonical target of nonsense-mediated mRNA decay in neuronal cells, and its deregulation impairs axonal and dendritic outgrowth, indicating a role in neural development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n With respect to cancer, ARHGAP24 appears to function as a tumor suppressor in several contexts. In triple-negative breast cancer, ARHGAP24 is antagonized by RASAL2, leading to enhanced Rac1 signaling and mesenchymal invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, diminished ARHGAP24 expression is associated with increased cell proliferation, invasion, and poorer outcomes in renal cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "as well as in lung cancer, where its restoration suppresses tumor growth and induces apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, ARHGAP24 has been identified among microRNA target gene networks that correlate with immune cell infiltration and tumor progression across multiple cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish ARHGAP24 as a multifaceted regulator of Rho GTPase activity. Its ability to modulate Rac1 and RhoA signaling is crucial for maintaining proper cellular architecture and function in normal physiology, while its dysregulation contributes to the pathogenesis of kidney diseases, aberrant neural development, and cancer progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benjamin P Fairfax, Seiko Makino, Jayachandran Radhakrishnan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2205"}], "href": "https://doi.org/10.1038/ng.2205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22446964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22446964"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hilma Holm, Daniel F Gudbjartsson, David O Arnar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Several common variants modulate heart rate, PR interval and QRS duration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.511"}], "href": "https://doi.org/10.1038/ng.511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20062063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20062063"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shreeram Akilesh, Hani Suleiman, Haiyang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI46458"}], "href": "https://doi.org/10.1172/JCI46458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21911940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21911940"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L S Nguyen, L Jolly, C Shoubridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2011.163"}], "href": "https://doi.org/10.1038/mp.2011.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22182939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22182939"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Min Feng, Yi Bao, Zhimei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASAL2 activates RAC1 to promote triple-negative breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI76711"}], "href": "https://doi.org/10.1172/JCI76711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25384218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25384218"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gaosi Xu, Xiongbing Lu, Tianlun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10386"}], "href": "https://doi.org/10.18632/oncotarget.10386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27385097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27385097"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lei Wang, Saie Shen, Haibo Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgz144"}], "href": "https://doi.org/10.1093/carcin/bgz144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31430374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31430374"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yue Zhao, Li Xu, Xinyu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12902"}], "href": "https://doi.org/10.1002/1878-0261.12902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33463006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33463006"}]}]}]}
Synonyms	FILGAP, RC-GAP72, P73RHOGAP, RCGAP72
Proteins	RHG24_HUMAN
NCBI Gene ID	83478
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARHGAP24 has 7,393 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for ARHGAP24 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARHGAP24 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ARHGAP24 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARHGAP24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARHGAP24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARHGAP24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGAP24 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP24 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP24 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGAP24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARHGAP24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGAP24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARHGAP24 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP24 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARHGAP24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARHGAP24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARHGAP24 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARHGAP24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARHGAP24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARHGAP24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARHGAP24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGAP24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARHGAP24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ARHGAP24 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ARHGAP24 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARHGAP24 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ARHGAP24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARHGAP24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARHGAP24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARHGAP24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARHGAP24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARHGAP24 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGAP24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARHGAP24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARHGAP24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ARHGAP24 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGAP24 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ARHGAP24 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ARHGAP24 from the GeneSigDB Published Gene Signatures dataset.