ARHGEF10L Gene

HGNC Family	Rho guanine nucleotide exchange factors (ARHGEF)
Name	Rho guanine nucleotide exchange factor (GEF) 10-like
Description	This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARHGEF10L is a member of the Rho guanine nucleotide exchange factor family that facilitates the activation of Rho GTPases, thereby modulating downstream signaling cascades important for cytoskeletal remodeling and cell motility. Multiple studies have demonstrated that aberrant expression or genetic variation of ARHGEF10L contributes to tumorigenesis. For example, increased ARHGEF10L expression in hepatocellular carcinoma has been shown to stimulate cell proliferation, migration, and epithelial‐to‐mesenchymal transition (EMT) by activating the RhoA–ROCK1–phospho‐ERM pathway, leading to decreased E‐cadherin and increased expression of mesenchymal markers such as N‐cadherin, vimentin, and Slug."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, genetic association studies have implicated ARHGEF10L variants in elevating susceptibility to basal cell carcinoma and ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", thereby underlining a role in tumor predisposition. Moreover, a circular RNA generated from the ARHGEF10L gene, known as circ_0010220, is upregulated in osteosarcoma and appears to promote tumor progression via regulation of the miR-198/Syntaxin 6 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Beyond oncology, ARHGEF10L has also emerged as a candidate gene in patients with cerebral visual impairment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings indicate that ARHGEF10L functions as a critical modulator of Rho GTPase signaling that fosters tumor cell growth, migration, and EMT in diverse malignancies, while its genetic alterations or dysregulated expression may also contribute to non-oncologic pathologies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junyi Tang, Chunyan Liu, Bing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2018.11.007"}], "href": "https://doi.org/10.1016/j.yexcr.2018.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30444969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30444969"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Da-Wei Wang, Jun-Yi Tang, Guo-Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2020.1737503"}], "href": "https://doi.org/10.1080/09168451.2020.1737503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32154766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32154766"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junyi Tang, Kehua Fang, Chang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Evid Based Complement Alternat Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6683264"}], "href": "https://doi.org/10.1155/2021/6683264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833821"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Simon N Stacey, Daniel F Gudbjartsson, Patrick Sulem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.234"}], "href": "https://doi.org/10.1038/ng.234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18849993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18849993"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Madalene Earp, Jonathan P Tyrer, Stacey J Winham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0197561"}], "href": "https://doi.org/10.1371/journal.pone.0197561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29979793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29979793"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhaoan Lu, Chuanwen Wang, Xiaolong Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbo.2021.100360"}], "href": "https://doi.org/10.1016/j.jbo.2021.100360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33996428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33996428"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Daniëlle G M Bosch, F Nienke Boonstra, Nicole de Leeuw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel genetic causes for cerebral visual impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.186"}], "href": "https://doi.org/10.1038/ejhg.2015.186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26350515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26350515"}]}]}]}
Synonyms	GRINCHGEF
Proteins	ARGAL_HUMAN
NCBI Gene ID	55160
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARHGEF10L has 5,908 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for ARHGEF10L from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARHGEF10L Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGEF10L gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGEF10L gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARHGEF10L gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARHGEF10L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARHGEF10L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARHGEF10L gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGEF10L gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGEF10L gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARHGEF10L gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARHGEF10L gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGEF10L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGEF10L gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARHGEF10L protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARHGEF10L gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGEF10L gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARHGEF10L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARHGEF10L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ARHGEF10L protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARHGEF10L gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARHGEF10L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARHGEF10L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARHGEF10L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARHGEF10L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARHGEF10L gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARHGEF10L gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARHGEF10L gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ARHGEF10L protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARHGEF10L gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ARHGEF10L gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ARHGEF10L gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARHGEF10L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARHGEF10L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARHGEF10L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARHGEF10L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARHGEF10L gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGEF10L gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARHGEF10L gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARHGEF10L from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ARHGEF10L gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARHGEF10L gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.