ARHGEF35 Gene

HGNC Family Rho guanine nucleotide exchange factors (ARHGEF)
Name Rho guanine nucleotide exchange factor (GEF) 35
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts directly mention "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF35"}]}, {"type": "t", "text": ", insights can be gleaned from studies reporting on related Rho guanine exchange factors (RhoGEFs). For instance, one study on colorectal cancer metastasis identified new components of multistage progression that include ARHGEF7 and ARHGEF33 (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Because ARHGEFs generally facilitate the activation of Rho family GTPases, they are well known for modulating actin cytoskeletal dynamics, cell adhesion, and cell–matrix interactions—processes central to cancer cell invasion and metastasis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In related work, alterations in cell adhesion have been implicated in the progression of malignancies such as thyroid and breast cancers, where changes in glycan processing"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and adhesion protein complexes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "were observed. These studies underscore the importance of adhesion-related signaling cascades and extracellular matrix interactions—a functional niche also occupied by RhoGEF family members.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, investigations in diverse contexts (e.g., vascular biology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", promoter evolution"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", endothelial function"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and comparative vascular proteomics"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "further emphasize that precise regulation of cell adhesion and cytoskeletal remodeling is critical in both normal physiology and disease. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Given this framework and by analogy to the functions described for other RhoGEF proteins, it is plausible that "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF35"}]}, {"type": "t", "text": " may serve a similar role by influencing actin reorganization and cell adhesion processes. Such functions could impact tumor progression and metastatic dissemination by modulating cellular interactions with the extracellular matrix. However, direct experimental evidence for ARHGEF35’s specific function is not provided in these abstracts, and further targeted studies would be necessary to clarify its precise role in cellular signaling and pathology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naveed Ishaque, Mohammed L Abba, Christine Hauser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07041-z"}], "href": "https://doi.org/10.1038/s41467-018-07041-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30429477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30429477"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Giancarlo Vecchio, Alessia Parascandolo, Chiara Allocca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15635"}], "href": "https://doi.org/10.18632/oncotarget.15635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28404918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28404918"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alice Beigbeder, François J M Chartier, Nicolas Bisson "}, {"type": "b", "children": [{"type": "t", "text": "MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-11876-9"}], "href": "https://doi.org/10.1038/s41598-017-11876-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28912526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28912526"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Soo Jung Lee, Soonhyung Kwon, John R Gatti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large-scale identification of human cerebrovascular proteins: Inter-tissue and intracerebral vascular protein diversity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0188540"}], "href": "https://doi.org/10.1371/journal.pone.0188540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29190776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29190776"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "N Nazaripanah, F Adelirad, A Delbari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-scale portrait and evolutionary significance of human-specific core promoter tri- and tetranucleotide short tandem repeats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-018-0149-3"}], "href": "https://doi.org/10.1186/s40246-018-0149-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29622039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29622039"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dragan Milenkovic, Wim Vanden Berghe, Christine Morand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-33959-x"}], "href": "https://doi.org/10.1038/s41598-018-33959-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30341379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30341379"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Soo Jung Lee, Sabrina Blanchett-Anderson, Simon G Keep, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite factors leading to molecular divergence between human and murine smooth muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0227672"}], "href": "https://doi.org/10.1371/journal.pone.0227672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31945134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31945134"}]}]}]}
Synonyms ARHGEF5L
Proteins ARG35_HUMAN
NCBI Gene ID 445328
API
Download Associations
Predicted Functions View ARHGEF35's ARCHS4 Predicted Functions.
Co-expressed Genes View ARHGEF35's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ARHGEF35's ARCHS4 Predicted Functions.

Functional Associations

ARHGEF35 has 1,759 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 47 datasets.

Click the + buttons to view associations for ARHGEF35 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ARHGEF35 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of ARHGEF35 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ARHGEF35 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of ARHGEF35 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGEF35 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of ARHGEF35 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ARHGEF35 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ARHGEF35 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of ARHGEF35 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with ARHGEF35 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of ARHGEF35 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by ARHGEF35 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with ARHGEF35 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ARHGEF35 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ARHGEF35 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARHGEF35 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of ARHGEF35 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing ARHGEF35 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ARHGEF35 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of ARHGEF35 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of ARHGEF35 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx eQTL 2025 SNPs regulating expression of ARHGEF35 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of ARHGEF35 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ARHGEF35 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ARHGEF35 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of ARHGEF35 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of ARHGEF35 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of ARHGEF35 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ARHGEF35 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for ARHGEF35 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of ARHGEF35 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate ARHGEF35 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of ARHGEF35 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of ARHGEF35 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of ARHGEF35 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for ARHGEF35 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ARHGEF35 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving ARHGEF35 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving ARHGEF35 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2024 pathways involving ARHGEF35 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ARHGEF35 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ARHGEF35 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ARHGEF35 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ARHGEF35 gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of ARHGEF35 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of ARHGEF35 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ARHGEF35 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.