{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts directly mention "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF35"}]}, {"type": "t", "text": ", insights can be gleaned from studies reporting on related Rho guanine exchange factors (RhoGEFs). For instance, one study on colorectal cancer metastasis identified new components of multistage progression that include ARHGEF7 and ARHGEF33 (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Because ARHGEFs generally facilitate the activation of Rho family GTPases, they are well known for modulating actin cytoskeletal dynamics, cell adhesion, and cell–matrix interactions—processes central to cancer cell invasion and metastasis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In related work, alterations in cell adhesion have been implicated in the progression of malignancies such as thyroid and breast cancers, where changes in glycan processing"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and adhesion protein complexes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "were observed. These studies underscore the importance of adhesion-related signaling cascades and extracellular matrix interactions—a functional niche also occupied by RhoGEF family members.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, investigations in diverse contexts (e.g., vascular biology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", promoter evolution"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", endothelial function"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and comparative vascular proteomics"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "further emphasize that precise regulation of cell adhesion and cytoskeletal remodeling is critical in both normal physiology and disease. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Given this framework and by analogy to the functions described for other RhoGEF proteins, it is plausible that "}, {"type": "b", "children": [{"type": "t", "text": "ARHGEF35"}]}, {"type": "t", "text": " may serve a similar role by influencing actin reorganization and cell adhesion processes. Such functions could impact tumor progression and metastatic dissemination by modulating cellular interactions with the extracellular matrix. However, direct experimental evidence for ARHGEF35’s specific function is not provided in these abstracts, and further targeted studies would be necessary to clarify its precise role in cellular signaling and pathology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naveed Ishaque, Mohammed L Abba, Christine Hauser, et al. 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