ARID3B Gene

HGNC Family	AT rich interactive domain containing (ARID)
Name	AT rich interactive domain 3B (BRIGHT-like)
Description	This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARID3B is a multifunctional AT‐rich DNA binding protein whose activity has been implicated in diverse aspects of development and oncogenesis. In several cancer models, ARID3B regulates gene expression programs that control cell fate decisions, stemness, and survival. For example, in ovarian and breast cancers, ARID3B expression is deregulated and is subject to post‐transcriptional control by microRNAs such as miR‐125a, miR‐125b, and let‐7, thereby influencing epithelial‐to‐mesenchymal transition, cell motility, and apoptotic responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In oral squamous and pancreatic cancers, ARID3B acts downstream of reprogramming factors such as Lin28B/Let-7 and miR-1291 to modulate the transcription of key stem cell regulators including Oct4 and Sox2, thereby contributing to the cancer stem cell phenotype and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In neural crest-derived tumors such as neuroblastoma, elevated ARID3B expression enhances malignant transformation and cooperates with oncogenes like MYCN, while its overexpression can immortalize fibroblasts in vitro, indicating a role in promoting tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, alternative splicing of ARID3B produces isoforms with distinct functional outcomes; for instance, full-length ARID3B has been shown to upregulate pro-apoptotic mediators and induce death receptor–mediated apoptosis, whereas shorter splice variants lack this capacity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " ARID3B also participates in p53-dependent transcriptional activation of pro-apoptotic target genes, further underscoring its role in the regulation of cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, in breast cancer, nuclear localization of ARID3B correlates with estrogen receptor positivity and lower tumor grade, suggesting a potential prognostic significance and context-dependent function in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karen D Cowden Dahl, Richard Dahl, Jessica N Kruichak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.09942"}], "href": "https://doi.org/10.1593/neo.09942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19881956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19881956"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shiva Akhavantabasi, Aysegul Sapmaz, Serkan Tuna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-125b targets ARID3B in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.11025"}], "href": "https://doi.org/10.1247/csf.11025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22307404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22307404"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tsai-Tsen Liao, Wen-Hao Hsu, Chien-Hsin Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.12.064"}], "href": "https://doi.org/10.1016/j.celrep.2015.12.064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26776511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26776511"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chian-Shiu Chien, Mong-Lien Wang, Pen-Yuan Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-2215"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-2215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25858147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25858147"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mei-Juan Tu, Pui Yan Ho, Qian-Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.10.038"}], "href": "https://doi.org/10.1016/j.canlet.2018.10.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30389433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30389433"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kenichiro Kobayashi, Takumi Era, Atsushi Takebe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-0756"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-0756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16951138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16951138"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "K Kobayashi, L M Jakt, S-I Nishikawa "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.285"}], "href": "https://doi.org/10.1038/onc.2012.285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22751132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22751132"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Stancy Joseph, Victoria E Deneke, Karen D Cowden Dahl "}, {"type": "b", "children": [{"type": "t", "text": "ARID3B induces tumor necrosis factor alpha mediated apoptosis while a novel ARID3B splice form does not induce cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042159"}], "href": "https://doi.org/10.1371/journal.pone.0042159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22860069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22860069"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Endrawan Pratama, Xiaohui Tian, Widya Lestari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.10.121"}], "href": "https://doi.org/10.1016/j.bbrc.2015.10.121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26519881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26519881"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ayse Selcen Oguz Erdogan, Nihan Ozdemirler, Merve Oyken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARID3B expression in primary breast cancers and breast cancer-derived cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-014-0185-5"}], "href": "https://doi.org/10.1007/s13402-014-0185-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25120063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25120063"}]}]}]}
Synonyms	BDP, DRIL2
Proteins	ARI3B_HUMAN
NCBI Gene ID	10620
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARID3B has 6,292 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for ARID3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARID3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARID3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARID3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARID3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARID3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARID3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARID3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARID3B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARID3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ARID3B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARID3B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARID3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARID3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARID3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARID3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARID3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARID3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ARID3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ARID3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ARID3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARID3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARID3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARID3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ARID3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ARID3B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARID3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ARID3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ARID3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARID3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARID3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARID3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ARID3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARID3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARID3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARID3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARID3B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ARID3B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARID3B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.