ARID5A Gene

HGNC Family	AT rich interactive domain containing (ARID)
Name	AT rich interactive domain 5A (MRF1-like)
Description	Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ARID5A is a multifunctional factor that plays a critical role in fine‐tuning inflammatory and immune responses through both post‐transcriptional and transcriptional mechanisms. In activated macrophages, ARID5A functions as an RNA‐binding protein that stabilizes key proinflammatory mRNAs—most notably interleukin‑6—by binding to their 3′ untranslated regions, thereby amplifying cytokine production and promoting inflammatory signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In T cells, ARID5A further contributes to immune regulation by selectively stabilizing the mRNA of signal transducer and activator of transcription 3 (STAT3) as well as T‑bet, which supports differentiation toward inflammatory Th17 and Th1 phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, ARID5A exhibits transcriptional co‑regulatory functions; its physical interaction with transcription factors such as SOX9 enhances the expression of chondrocyte‑specific genes, thereby contributing to cartilage development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " ARID5A localizes to both the nucleus and cytoplasm and undergoes dynamic nucleocytoplasmic shuttling in response to inflammatory stimuli—a regulatory mechanism that ensures precise control over its dual activities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, ARID5A can be induced downstream of IL‑6 signaling itself, forming positive feedback loops that exacerbate pathological inflammation in a variety of contexts, including autoimmune diseases, septic shock, and even cancer metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these studies underscore the central role of ARID5A as a molecular switch that integrates signals from microbial and cytokine stimuli to modulate the stability of inflammatory mRNAs and the activity of transcriptional programs, thereby shaping both innate and adaptive immune responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kazuya Masuda, Barry Ripley, Riko Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1307419110"}], "href": "https://doi.org/10.1073/pnas.1307419110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23676272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23676272"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kishan K Nyati, Kazuya Masuda, Mohammad Mahabub-Uz Zaman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx064"}], "href": "https://doi.org/10.1093/nar/gkx064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28168301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28168301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kazuya Masuda, Barry Ripley, Kishan Kumar Nyati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20151289"}], "href": "https://doi.org/10.1084/jem.20151289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27022145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27022145"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mohammad Mahabub-Uz Zaman, Kazuya Masuda, Kishan Kumar Nyati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1613307113"}], "href": "https://doi.org/10.1073/pnas.1613307113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27671645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27671645"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Katsuhiko Amano, Kenji Hata, Shuji Muramatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-07-0566"}], "href": "https://doi.org/10.1091/mbc.E10-07-0566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21346191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21346191"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mitsuru Higa, Masahiro Oka, Yoshitaka Fujihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1719921115"}], "href": "https://doi.org/10.1073/pnas.1719921115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358370"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.08.004"}], "href": "https://doi.org/10.1016/j.canlet.2021.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34389433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34389433"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kishan Kumar Nyati, Mohammad Mahabub-Uz Zaman, Praveen Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arid5a, an RNA-Binding Protein in Immune Regulation: RNA Stability, Inflammation, and Autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.it.2020.01.004"}], "href": "https://doi.org/10.1016/j.it.2020.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32035762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32035762"}]}]}]}
Synonyms	RP11-363D14, MRF-1
Proteins	ARI5A_HUMAN
NCBI Gene ID	10865
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ARID5A has 6,076 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for ARID5A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ARID5A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID5A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID5A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ARID5A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ARID5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ARID5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ARID5A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ARID5A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARID5A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ARID5A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ARID5A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARID5A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ARID5A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ARID5A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARID5A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ARID5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ARID5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ARID5A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ARID5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ARID5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ARID5A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ARID5A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ARID5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ARID5A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ARID5A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ARID5A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ARID5A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ARID5A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ARID5A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ARID5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ARID5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ARID5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ARID5A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ARID5A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ARID5A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ARID5A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ARID5A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ARID5A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ARID5A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ARID5A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ARID5A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.