{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted a potential multifaceted role for ARL14EPL in cancer biology, suggesting that it may serve as a critical regulator at the crossroads of epigenetic control, apoptosis, immune modulation, and autophagy‐associated signaling. Data derived from diverse experimental systems indicate that ARL14EPL influences cellular sensitivity to pro‐apoptotic cues. In glioblastoma models, for example, agents that trigger oxidative stress and DNA damage—via ROS generation and p53‐dependent pathways—can prime tumor cells for apoptosis; such processes are thought to intersect with ARL14EPL activity in modulating the cellular apoptotic threshold."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, transcriptomic analyses of whole‐blood samples following metformin treatment have revealed alterations in genes linked to cytokine signaling and intestinal immune responses, thereby raising the possibility that ARL14EPL may contribute to the regulation of immune networks in metabolic contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in endometrial cancer, integration of autophagy‐related long non‐coding RNA profiles into prognostic models has implicated key signaling pathways—including JAK‐STAT and MAPK—where ARL14EPL might serve as an important molecular node that refines patient outcome predictions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, although less directly explored, earlier evidence suggests that ARL14EPL may also be involved in epigenetic regulation events that impact cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings support a model whereby ARL14EPL functions as an integrative modulator of apoptosis, immune response, and cellular stress signaling, reinforcing its promise as both a therapeutic target and a prognostic biomarker in diverse oncological settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ezgi Ozyerli-Goknar, Ilknur Sur-Erdem, Fidan Seker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2107-y"}], "href": "https://doi.org/10.1038/s41419-019-2107-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31772153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31772153"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Monta Briviba, Ivars Silamikelis, Ineta Kalnina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0224835"}], "href": "https://doi.org/10.1371/journal.pone.0224835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31703101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31703101"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Heng Liu, Yanxiang Cheng "}, {"type": "b", "children": [{"type": "t", "text": "Identification of autophagy-related long non-coding RNAs in endometrial cancer via comprehensive bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Womens Health (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12905-022-01667-4"}], "href": "https://doi.org/10.1186/s12905-022-01667-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35321716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35321716"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhe Wang, Zhongmiao Wang, Xing Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of seven-gene signature for prediction of lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S198998"}], "href": "https://doi.org/10.2147/OTT.S198998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31440059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31440059"}]}]}]}