{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Activating signal cointegrator 1 complex subunit 3 (ASCC3) functions as a versatile helicase that integrates multiple cellular processes. ASCC3 is a core component of the ASCC complex and plays a critical role in DNA repair by unwinding DNA to generate the single‐stranded substrates required for the demethylase ALKBH3, thereby facilitating the repair of alkylation damage in DNA and RNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, ASCC3 is involved in the cellular response to ultraviolet‐induced DNA damage where alternative transcript isoforms with opposing functions are produced; a short non‐coding isoform of ASCC3 counteracts its protein‐coding counterpart to promote recovery of transcription following UV exposure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Beyond its role in nucleic acid repair, ASCC3 also acts as a negative regulator of the innate immune response. It modulates the expression of interferon‐stimulated genes in an IRF‐3/IRF‐7–dependent manner, thereby tempering the antiviral state and influencing viral infection outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, recent studies have highlighted a pivotal function for ASCC3 in ribosome quality control. As part of a mammalian ribosome quality control trigger complex (hRQT), which also comprises ASCC2 and TRIP4, the ATPase activity of ASCC3 is required for disassembling collided ribosomes during stalled translation events, ensuring proper clearance and recycling of ribosomal subunits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " In addition, genetic studies associate variations in ASCC3 with altered disease outcomes, including persistent hepatitis B virus infection and modulation of antidepressant response, underscoring its potential clinical significance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, as an integral subunit of the ASC‐1 transcriptional coactivator complex, ASCC3 contributes to the broader regulation of gene expression and chromatin dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sebastian Dango, Nima Mosammaparast, Mathew E Sowa, et al. 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