ATF7 Gene

HGNC Family	Basic leucine zipper proteins
Name	activating transcription factor 7
Description	Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ATF7 is emerging as a multifaceted transcription factor that integrates diverse cellular signals to regulate cell cycle progression, stress responses, and differentiation in both normal development and disease. For example, ATF7’s activity is modulated by phosphorylation events—such as by CDK1/cyclin B1 during mitosis—which stabilize the protein and promote the expression of key regulators like cyclin D1, with combined loss or mutation of ATF7 contributing to embryonic lethality and cell cycle defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " \n Post‐translational modifications—most notably the antagonistic interplay between phosphorylation and sumoylation, and even alternative splicing (yielding ATF7‑4 that sequesters upstream kinases in the cytoplasm)—further refine its nuclear localization and transcriptional potency."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncogenic contexts, ATF7 plays complex, sometimes opposing roles. In hepatocellular carcinoma, for instance, miR‐mediated targeting of ATF7 releases a brake on cell proliferation and apoptosis, while in hematopoietic malignancies ATF7 participates in AP‑1 complexes that help direct transcriptional programs in lymphoid cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, clinical correlations demonstrate that higher ATF7 expression is linked to favorable outcomes in colorectal cancer and that its loss in HER2‐positive breast cancers is associated with enhanced migration and metastasis, with additional studies revealing its involvement in triple‐negative breast cancer metastasis suppression through a long noncoding RNA–miRNA axis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ATF7 also contributes to the regulation of cellular differentiation and stress responses. In bone, for instance, ATF7 physically interacts with the transcriptional coactivator TAF12 in osteoclast precursors, thereby modulating sensitivity to vitamin D and interleukin‑6 expression as part of the pathological process seen in Paget’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In parallel, investigations in B‑cell lineages show that deletion of ATF7 (often together with ATF2) accelerates lymphoma progression, underlining its importance in maintaining proper cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Studies in Caenorhabditis elegans further implicate the ortholog of ATF7 in orchestrating responses to oxidative stress—upregulating metallothionein expression and promoting stress resistance—and even in influencing organismal lifespan, findings that are reinforced by observations of increased atf‑7 expression in response to stress‐protective treatments."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}, {"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in the heart, an exercise‐induced long noncoding RNA regulates ATF7 via interactions with RNA helicases and transcriptional repressors to facilitate physiological cardiac hypertrophy and confer cardioprotection, highlighting the role of ATF7 as an effector of adaptive remodeling in response to external stimuli."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " \n Collectively, these studies portray ATF7 as a key node that—depending on its modification status and interacting partners—governs transcriptional programs critical for cell cycle control, stress adaptation, differentiation, and disease progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wolfgang Breitwieser, Steve Lyons, Ann Marie Flenniken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.430207"}], "href": "https://doi.org/10.1101/gad.430207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17699753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17699753"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hitomi Hasegawa, Kenichi Ishibashi, Shoichi Kubota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0116048"}], "href": "https://doi.org/10.1371/journal.pone.0116048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25545367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25545367"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Etienne Schaeffer, Marc Vigneron, Annie-Paule Sibler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2015.1064568"}], "href": "https://doi.org/10.1080/15384101.2015.1064568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26101806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26101806"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Barbara Camuzeaux, Jessica Diring, Pierre-Jacques Hamard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.10.008"}], "href": "https://doi.org/10.1016/j.jmb.2008.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18950637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18950637"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jessica Diring, Barbara Camuzeaux, Mariel Donzeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0023351"}], "href": "https://doi.org/10.1371/journal.pone.0023351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21858082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21858082"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pierre-Jacques Hamard, Michaël Boyer-Guittaut, Barbara Camuzeaux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkl1168"}], "href": "https://doi.org/10.1093/nar/gkl1168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17264123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17264123"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaoyi Hu, Jiyu Miao, Min Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2018.2078"}], "href": "https://doi.org/10.14348/molcells.2018.2078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29754469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29754469"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Luca Grumolato, Guizhong Liu, Tomomi Haremaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1003603"}], "href": "https://doi.org/10.1371/journal.pgen.1003603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23966864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23966864"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mélanie Juilland, Montserrat Gonzalez, Tabea Erdmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-07-655647"}], "href": "https://doi.org/10.1182/blood-2015-07-655647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26747248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26747248"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Feifei Song, Mingcong Wei, Jingwen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14004"}], "href": "https://doi.org/10.1111/cas.14004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30891870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30891870"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong-Qiang Guo, Sheng Ye, Guo-Liang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/0973-1482.148688"}], "href": "https://doi.org/10.4103/0973-1482.148688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26148593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26148593"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Juli Lin, Hehui Mao, Zhuannan Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human epidermal growth factor receptor 2 inhibits activating transcription factor 7 to promote breast cancer cell migration by activating histone lysine demethylase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/jcrt.jcrt_649_21"}], "href": "https://doi.org/10.4103/jcrt.jcrt_649_21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34850767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34850767"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jinfeng Zhang, Donghua Liu, Guoming Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2003928"}], "href": "https://doi.org/10.1080/21655979.2021.2003928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34787047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34787047"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jennifer L Mamrosh, Jae Man Lee, Martin Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.01694"}], "href": "https://doi.org/10.7554/eLife.01694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24737860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24737860"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Julie A Hall, Matthew K McElwee, Jonathan H Freedman "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0177432"}], "href": "https://doi.org/10.1371/journal.pone.0177432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28632756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28632756"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "J Walczynski, S Lyons, N Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.28"}], "href": "https://doi.org/10.1038/onc.2013.28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23416976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23416976"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Toshio Maekawa, Binbin Liu, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress-induced and ATF7-dependent epigenetic change influences cellular senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12713"}], "href": "https://doi.org/10.1111/gtc.12713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31294895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31294895"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xueke Cao, Yu Zhang, Yundi Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impacts of konjac glucomannan with different degree of degradation or deacetylation on the stress resistance and fitness in Caenorhabditis elegans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2022.01.161"}], "href": "https://doi.org/10.1016/j.ijbiomac.2022.01.161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35114273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35114273"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Olli Matilainen, Ana R S Ribeiro, Jens Verbeeren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/genetics/iyab114"}], "href": "https://doi.org/10.1093/genetics/iyab114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34849877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34849877"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Rongrong Gao, Lijun Wang, Yihua Bei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Cardiac Physiological Hypertrophy-Associated Regulator Induces Cardiac Physiological Hypertrophy and Promotes Functional Recovery After Myocardial Ischemia-Reperfusion Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.120.050446"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.120.050446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34015936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34015936"}]}]}]}
Synonyms	ATFA
Proteins	ATF7_HUMAN
NCBI Gene ID	11016
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ATF7 has 5,952 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 129 datasets.

Click the + buttons to view associations for ATF7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ATF7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ATF7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATF7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATF7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ATF7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ATF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ATF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATF7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ATF7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATF7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATF7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ATF7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATF7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ATF7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ATF7 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATF7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ATF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ATF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ATF7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ATF7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ATF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ATF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ATF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ATF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATF7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ATF7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with ATF7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ATF7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ATF7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ATF7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate ATF7 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ATF7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ATF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ATF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ATF7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ATF7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ATF7 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ATF7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATF7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ATF7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ATF7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.