ATP6V1F Gene

HGNC Family	ATPases
Name	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
Description	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c`, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ATP6V1F encodes a highly conserved subunit (subunit F) of the vacuolar‐type H<sup>+</sup>-ATPase complex that is critical for coupling ATP hydrolysis to proton translocation and thereby for acidifying intracellular compartments. Studies cloning ATP6V1F from diverse species, including the Giant Panda"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and extensive work in yeast models, have demonstrated that subunit F (also known as Vma7p) is essential for the proper assembly and stability of the V1 sector of the ATPase. Yeast genetic and biochemical analyses have shown that loss or dysfunction of subunit F impairs vacuolar acidification, disrupts the assembly of the catalytic complex, and results in growth defects and altered pH homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": " Similarly, in pathogenic fungi such as Candida albicans, disruption of the ATP6V1F homolog leads to defects in vacuolar ion transport, diminished hyphal growth, and loss of virulence, thereby underlining its central role in maintaining cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In vertebrate systems, proper function of the V-ATPase—including subunit F—is necessary for the maturation of specialized cells and organ development, as illustrated by studies in zebrafish showing that mutations affecting ATPase components result in ocular malformations and compromised retinal pigment epithelium function"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and structural analyses by small-angle X-ray scattering have further defined the molecular architecture of subunit F and its role in energy coupling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, clinical investigations have associated lower expression levels of ATP6V1F with more advanced tumor stages and poorer overall survival in kidney renal clear cell carcinoma, suggesting that ATP6V1F may serve both as a prognostic marker and a potential therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Jie Du, Yi-Ling Hou, Wan-Ru Hou "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and overexpression of an important functional gene ATP6V1F encoding a component of vacuolar ATPase from the Giant Panda (Ailuropoda melanoleuca)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-011-1386-x"}], "href": "https://doi.org/10.1007/s11033-011-1386-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22212708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22212708"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H Nelson, S Mandiyan, N Nelson "}, {"type": "b", "children": [{"type": "t", "text": "The Saccharomyces cerevisiae VMA7 gene encodes a 14-kDa subunit of the vacuolar H(+)-ATPase catalytic sector."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (1994)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7929071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7929071"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J J Tomashek, J L Sonnenburg, J M Artimovich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resolution of subunit interactions and cytoplasmic subcomplexes of the yeast vacuolar proton-translocating ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (1996)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.271.17.10397"}], "href": "https://doi.org/10.1074/jbc.271.17.10397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8626613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8626613"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J J Tomashek, L A Graham, M U Hutchins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "V1-situated stalk subunits of the yeast vacuolar proton-translocating ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (1997)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.272.42.26787"}], "href": "https://doi.org/10.1074/jbc.272.42.26787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "9334266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/9334266"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "R P Jones, I E Hunt, J Jaeger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, purification and secondary structure analysis of Saccharomyces cerevisiae vacuolar membrane H+-ATPase subunit F (Vma7p)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Membr Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09687680110099538"}], "href": "https://doi.org/10.1080/09687680110099538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11780757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11780757"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Keren Aviezer-Hagai, Vered Padler-Karavani, Nathan Nelson "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical support for the V-ATPase rotary mechanism: antibody against HA-tagged Vma7p or Vma16p but not Vma10p inhibits activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jeb.00543"}], "href": "https://doi.org/10.1242/jeb.00543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12909704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12909704"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sophia Poltermann, Monika Nguyen, Juliane Günther, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbiology (Reading) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/mic.0.27505-0"}], "href": "https://doi.org/10.1099/mic.0.27505-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870472"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Raimund Eck, Monika Nguyen, Juliane Günther, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ -ATPase subunit Vma7p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Microbiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijmm.2004.12.007"}], "href": "https://doi.org/10.1016/j.ijmm.2004.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15861817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15861817"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Richard J Nuckels, Anthony Ng, Tristan Darland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The vacuolar-ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.08-2743"}], "href": "https://doi.org/10.1167/iovs.08-2743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18836173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18836173"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sandip Basak, Shovanlal Gayen, Youg R Thaker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution structure of subunit F (Vma7p) of the eukaryotic V(1)V(O) ATPase from Saccharomyces cerevisiae derived from SAXS and NMR spectroscopy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2010.09.003"}], "href": "https://doi.org/10.1016/j.bbamem.2010.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20840841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20840841"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiaojuan Li, Hao Li, Caihong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of ATP6V1s Family Members in Renal Clear Cell Carcinoma With Prognostic Values."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.567970"}], "href": "https://doi.org/10.3389/fonc.2020.567970"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33194650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33194650"}]}]}]}
Synonyms	VATF, VMA7, ATP6S14
Proteins	VATF_HUMAN
NCBI Gene ID	9296
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ATP6V1F has 6,097 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for ATP6V1F from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ATP6V1F Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATP6V1F gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATP6V1F gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ATP6V1F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ATP6V1F gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATP6V1F gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ATP6V1F gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATP6V1F gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATP6V1F gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATP6V1F gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ATP6V1F gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ATP6V1F protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ATP6V1F gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATP6V1F gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ATP6V1F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ATP6V1F gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ATP6V1F gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ATP6V1F protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ATP6V1F protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ATP6V1F protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ATP6V1F protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ATP6V1F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ATP6V1F protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATP6V1F gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ATP6V1F gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ATP6V1F gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ATP6V1F gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ATP6V1F protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ATP6V1F gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ATP6V1F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ATP6V1F gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ATP6V1F gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ATP6V1F gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATP6V1F gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ATP6V1F gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ATP6V1F from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ATP6V1F gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ATP6V1F gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ATP6V1F from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ATP6V1F gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of ATP6V1F gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.