ATXN7 Gene

HGNC Family	Ataxins (ATXN)
Name	ataxin 7
Description	The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAtaxin‐7 (ATXN7) is a multifunctional protein that plays a central role in regulating gene expression. It is a critical subunit of the SAGA‐ and TFTC‐like transcription coactivator complexes, where it interacts directly with the GCN5 histone acetyltransferase and other chromatin‐modifying enzymes to facilitate histone acetylation and proper chromatin remodeling. Through these interactions, ATXN7 also mediates contacts with specific transcription factors (for example, CRX and partners) to activate target genes such as reelin, thereby linking chromatin dynamics to cell type–specific transcriptional programs. Structural analyses have revealed conserved domains—including a zinc‐binding motif—that are essential for its incorporation into these complexes and for its transcription‐regulatory function, as further supported by studies identifying novel ATXN7 protein–protein interactions in ataxia‐related networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn its disease‐associated polyglutamine–expanded form, ATXN7 exhibits altered conformational dynamics that promote misfolding and aggregation. Biophysical and cell‐based investigations have demonstrated that expansion of the polyglutamine tract—often modulated by a preceding alanine‐rich region—enhances the propensity of ATXN7 to form nuclear inclusions. Post‐translational modifications such as SUMOylation regulate both its aggregation behavior and its clearance through the ubiquitin–proteasome system and autophagy, while pathogenic forms of ATXN7 can sequester deubiquitinase components (for instance, USP22) thereby impairing histone H2B deubiquitination. Collectively, these studies underscore how altered ATXN7 structure and misregulated clearance mechanisms may contribute to transcriptional dysregulation and cellular toxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical nuclear functions, ATXN7 has been implicated in critical developmental and cytoplasmic roles. In vivo models, including zebrafish, demonstrate that proper levels of ATXN7 are required for the differentiation of photoreceptors and cerebellar neurons, which is consistent with the selective neuronal vulnerability observed in spinocerebellar ataxia type 7 (SCA7). In addition, cytoplasmic ATXN7 dynamically shuttles between subcellular compartments and associates with microtubules to stabilize cytoskeletal organization. Recent work has also uncovered non‐neuronal functions, such as the regulation by a circular RNA derived from ATXN7 (circATXN7), which modulates NF‐κB signaling and cell fate decisions in T lymphocytes. Furthermore, ATXN7 aggregates have been shown to recruit other RNA‐binding proteins like FUS, potentially exacerbating cellular dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dominique Helmlinger, Sara Hardy, Souphatta Sasorith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddh139"}], "href": "https://doi.org/10.1093/hmg/ddh139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15115762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15115762"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vikas B Palhan, Shiming Chen, Guang-Hua Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0503505102"}], "href": "https://doi.org/10.1073/pnas.0503505102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15932940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15932940"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anna-Lena Ström, Lars Forsgren, Monica Holmberg "}, {"type": "b", "children": [{"type": "t", "text": "A role for both wild-type and expanded ataxin-7 in transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2005.04.018"}], "href": "https://doi.org/10.1016/j.nbd.2005.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15936949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15936949"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tara L Burke, Jaime L Miller, Patrick A Grant "}, {"type": "b", "children": [{"type": "t", "text": "Direct inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.487538"}], "href": "https://doi.org/10.1074/jbc.M113.487538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24129567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24129567"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shaun D McCullough, Xiaojiang Xu, Sharon Y R Dent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1218331110"}], "href": "https://doi.org/10.1073/pnas.1218331110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23236151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23236151"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Juliette J Kahle, Natali Gulbahce, Chad A Shaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq496"}], "href": "https://doi.org/10.1093/hmg/ddq496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21078624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21078624"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jacques Bonnet, Ying-Hui Wang, Gianpiero Spedale, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp478"}], "href": "https://doi.org/10.1093/hmg/ddp478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19843541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19843541"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C Zander, J Takahashi, K H El Hachimi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/10.22.2569"}], "href": "https://doi.org/10.1093/hmg/10.22.2569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11709544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11709544"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Morwena Latouche, Pascal Fragner, Elodie Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyglutamine and polyalanine expansions in ataxin7 result in different types of aggregation and levels of toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2005.10.013"}], "href": "https://doi.org/10.1016/j.mcn.2005.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16325416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16325416"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jun-Ye Hong, Dong-Dong Wang, Wei Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43926-9"}], "href": "https://doi.org/10.1038/s41598-019-43926-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31097749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31097749"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Martina Marinello, Andreas Werner, Mariagiovanna Giannone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.036145"}], "href": "https://doi.org/10.1242/dmm.036145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30559154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30559154"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xin Yu, Abiodun Ajayi, Narasimha Rao Boga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-012-9722-8"}], "href": "https://doi.org/10.1007/s12031-012-9722-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22367614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22367614"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hui Yang, Shuai Liu, Wen-Tian He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.631663"}], "href": "https://doi.org/10.1074/jbc.M114.631663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26195632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26195632"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xianjiang Lan, Evangelia Koutelou, Andria C Schibler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01454-14"}], "href": "https://doi.org/10.1128/MCB.01454-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25755283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25755283"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Constantin Yanicostas, Elisa Barbieri, Masahiko Hibi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0050705"}], "href": "https://doi.org/10.1371/journal.pone.0050705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23226359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23226359"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yoko Nakamura, Kazuhiko Tagawa, Tsutomu Oka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr539"}], "href": "https://doi.org/10.1093/hmg/ddr539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22100762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22100762"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Chi Zhou, Wenxin Li, Zhenxing Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-44779-1"}], "href": "https://doi.org/10.1038/s41467-024-44779-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38216551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38216551"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Frida Niss, Wajiha Zaidi, Einar Hallberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyglutamine expanded Ataxin-7 induces DNA damage and alters FUS localization and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2020.103584"}], "href": "https://doi.org/10.1016/j.mcn.2020.103584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33338633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33338633"}]}]}]}
Synonyms	SCA7, ADCAII, OPCA3, SGF73
Proteins	ATX7_HUMAN
NCBI Gene ID	6314
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ATXN7 has 6,271 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for ATXN7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ATXN7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ATXN7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATXN7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATXN7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ATXN7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ATXN7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ATXN7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ATXN7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATXN7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ATXN7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATXN7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ATXN7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ATXN7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ATXN7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATXN7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ATXN7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ATXN7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ATXN7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ATXN7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ATXN7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ATXN7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ATXN7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ATXN7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ATXN7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ATXN7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ATXN7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ATXN7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ATXN7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ATXN7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ATXN7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ATXN7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ATXN7 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ATXN7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ATXN7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ATXN7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ATXN7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ATXN7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ATXN7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ATXN7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ATXN7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ATXN7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.