AURKA Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	aurora kinase A
Description	The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Aurora kinase A (AURKA) is a multifunctional serine/threonine kinase that plays central roles in both mitotic and non‐mitotic cellular processes. In its well‐established mitotic functions, AURKA regulates centrosome maturation, spindle assembly, and proper chromosome segregation by phosphorylating key substrates such as Polo‐like kinase 1 (PLK1) and CDC25B, often in cooperation with cofactors like Bora and TPX2."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Beyond its canonical mitotic duties, AURKA also exerts non‐mitotic functions such as promoting ciliary disassembly via activation of HDAC6 following interaction with adhesion‐related scaffold proteins like HEF1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, aberrant expression or mutation of AURKA—exemplified by oncogenic variants such as the F31I substitution—contributes to chromosomal instability and tumorigenesis in several cancers, including pancreatic, ovarian, hepatocellular, and breast malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": " In addition to driving mitotic progression, AURKA promotes oncogenesis by stabilizing key oncoproteins—such as N‐Myc and MYC—thereby protecting them from proteasomal degradation via interplay with components like the SCF^FBXW7 complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "19"}]}, {"type": "t", "text": " These oncogenic properties have spurred the development of selective AURKA inhibitors—such as alisertib—which not only disrupt AURKA’s catalytic activity but also interfere with its kinase‐independent functions, leading to mitotic abnormalities, impaired tumor cell proliferation, and enhanced sensitivity to other targeted therapies in contexts like EGFR‐mutant lung adenocarcinoma and neuroendocrine prostate cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "23"}]}, {"type": "t", "text": " Overall, accumulating evidence—including detailed reviews"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "26"}]}, {"type": "t", "text": "—illustrates that AURKA integrates diverse processes from cell cycle control to ciliary dynamics, making its dysregulation a driving force in oncogenesis as well as an attractive target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patrick Meraldi, Reiko Honda, Erich A Nigg "}, {"type": "b", "children": [{"type": "t", "text": "Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/21.4.483"}], "href": "https://doi.org/10.1093/emboj/21.4.483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11847097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11847097"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Libor Macůrek, Arne Lindqvist, Dan Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07185"}], "href": "https://doi.org/10.1038/nature07185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18615013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18615013"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Akiko Seki, Judith A Coppinger, Chang-Young Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1157425"}], "href": "https://doi.org/10.1126/science.1157425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18566290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18566290"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas A Kufer, Herman H W Silljé, Roman Körner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human TPX2 is required for targeting Aurora-A kinase to the spindle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200204155"}], "href": "https://doi.org/10.1083/jcb.200204155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12177045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12177045"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stéphanie Dutertre, Martine Cazales, Muriel Quaranta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01108"}], "href": "https://doi.org/10.1242/jcs.01108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15128871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15128871"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Elena N Pugacheva, Sandra A Jablonski, Tiffiney R Hartman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HEF1-dependent Aurora A activation induces disassembly of the primary cilium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.04.035"}], "href": "https://doi.org/10.1016/j.cell.2007.04.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17604723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17604723"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Elena N Pugacheva, Erica A Golemis "}, {"type": "b", "children": [{"type": "t", "text": "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1309"}], "href": "https://doi.org/10.1038/ncb1309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16184168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16184168"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Donghui Li, Jijiang Zhu, Pervez F Firozi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12631597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12631597"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tatiana M Gritsko, Domenico Coppola, June E Paciga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12684414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12684414"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yung-Ming Jeng, Shian-Yang Peng, Chiao-Ying Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression and amplification of Aurora-A in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.ccr-1057-03"}], "href": "https://doi.org/10.1158/1078-0432.ccr-1057-03"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15041727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15041727"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djj374"}], "href": "https://doi.org/10.1093/jnci/djj374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17018785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17018785"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tobias Otto, Sebastian Horn, Markus Brockmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2008.12.005"}], "href": "https://doi.org/10.1016/j.ccr.2008.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19111882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19111882"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chien-Hung Yeh, Marcia Bellon, Christophe Nicot "}, {"type": "b", "children": [{"type": "t", "text": "FBXW7: a critical tumor suppressor of human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0857-2"}], "href": "https://doi.org/10.1186/s12943-018-0857-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30086763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30086763"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jian-Hua Mao, Jesus Perez-Losada, Di Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03155"}], "href": "https://doi.org/10.1038/nature03155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15592418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15592418"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Amanda Ewart-Toland, Paraskevi Briassouli, John P de Koning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1220"}], "href": "https://doi.org/10.1038/ng1220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12881723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12881723"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "John K Lee, John W Phillips, Bryan A Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.03.001"}], "href": "https://doi.org/10.1016/j.ccell.2016.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27050099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27050099"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "William Clay Gustafson, Justin Gabriel Meyerowitz, Erin A Nekritz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Drugging MYCN through an allosteric transition in Aurora kinase A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2014.07.015"}], "href": "https://doi.org/10.1016/j.ccr.2014.07.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25175806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25175806"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Juan Miguel Mosquera, Himisha Beltran, Kyung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.121550"}], "href": "https://doi.org/10.1593/neo.121550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23358695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23358695"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Daniel Dauch, Ramona Rudalska, Giacomo Cossa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4107"}], "href": "https://doi.org/10.1038/nm.4107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27213815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27213815"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mark G Manfredi, Jeffrey A Ecsedy, Arijit Chakravarty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-11-1536"}], "href": "https://doi.org/10.1158/1078-0432.CCR-11-1536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22016509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22016509"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Fiona Girdler, Karen E Gascoigne, Patrick A Eyers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Validating Aurora B as an anti-cancer drug target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03145"}], "href": "https://doi.org/10.1242/jcs.03145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16912073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16912073"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Khyati N Shah, Roma Bhatt, Julia Rotow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-018-0264-7"}], "href": "https://doi.org/10.1038/s41591-018-0264-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30478424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30478424"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Himisha Beltran, Clara Oromendia, Daniel C Danila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-18-1912"}], "href": "https://doi.org/10.1158/1078-0432.CCR-18-1912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30232224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30232224"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Anna S Nikonova, Igor Astsaturov, Ilya G Serebriiskii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aurora A kinase (AURKA) in normal and pathological cell division."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-012-1073-7"}], "href": "https://doi.org/10.1007/s00018-012-1073-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22864622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22864622"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Renjie Wang, Sai Zhang, Xuyi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0911-0"}], "href": "https://doi.org/10.1186/s12943-018-0911-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30470262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30470262"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "B Goldenson, J D Crispino "}, {"type": "b", "children": [{"type": "t", "text": "The aurora kinases in cell cycle and leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.14"}], "href": "https://doi.org/10.1038/onc.2014.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24632603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24632603"}]}]}]}
Synonyms	STK15, AIK, AURORA2, STK6, AURA, ARK1, BTAK, PPP1R47
Proteins	AURKA_HUMAN
NCBI Gene ID	6790
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

AURKA has 17,948 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.

Click the + buttons to view associations for AURKA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

AURKA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AURKA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of AURKA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of AURKA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of AURKA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of AURKA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving AURKA protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of AURKA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AURKA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of AURKA gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of AURKA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of AURKA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with AURKA gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with AURKA protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with AURKA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AURKA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of AURKA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of AURKA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of AURKA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing AURKA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing AURKA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing AURKA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing AURKA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with AURKA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with AURKA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing AURKA protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of AURKA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with AURKA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with AURKA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with AURKA gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of AURKA protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate AURKA protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving AURKA gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving AURKA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with AURKA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with AURKA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with AURKA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with AURKA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for AURKA protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at AURKA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of AURKA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.