| Name | antizyme inhibitor 2 |
| Description | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Antizyme inhibitor 2 (AZIN2) is emerging as a tissue‐specific regulator of polyamine metabolism that extends well beyond simply modulating cell proliferation. Studies in cardiac tissue have identified an alternatively spliced variant (AZIN2‐sv) that negatively regulates cardiomyocyte proliferation via stabilization of PTEN and inhibition of Akt signaling, thereby suppressing endogenous cardiac regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In other systems, the mouse ODC‐like protein (ODCp) has been shown to function as an antizyme inhibitory protein—now recognized as AZIN2—rescinding antizyme‐mediated degradation of ornithine decarboxylase and consequently promoting polyamine synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In mast cells, AZIN2 expression localizes specifically to a subset of secretory granules (those containing serotonin) and is rapidly upregulated upon activation. This selective localization supports a specialized role in regulating vesicular exocytosis and polyamine‐dependent secretion, which in turn modulates the release of serotonin and influences inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Consistent with this secretory function, transfection studies demonstrate that both human and mouse AZIN2 can stimulate polyamine uptake by countering the inhibitory effects of antizymes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n A broader review of AZIN2’s molecular and cellular properties indicates that, unlike its ubiquitously expressed paralogue AZIN1, AZIN2 is predominantly found in differentiated cells of the brain and testis. In neuronal cells, AZIN2 exhibits a “pearl‐on‐the‐string” distribution along axons and co‐localizes with N‐methyl-D-aspartate receptors; its accumulation in Alzheimer’s disease brains suggests potential links to tau pathology and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, AZIN2’s localization to the endoplasmic reticulum–Golgi intermediate compartment and cis-Golgi network has been implicated in the regulation of secretory vesicle trafficking, where local activation of ODC and polyamine biosynthesis appears to facilitate efficient protein secretion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In tauopathies, sustained overexpression of AZIN2 has been associated with increased acetylpolyamine levels, enhanced tau deposition, and behavioral impairments, thereby integrating polyamine metabolism into the pathological feed-forward cycle characteristic of neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the gonads, AZIN2 is robustly expressed in steroidogenic cells—such as Leydig cells in the testis and luteinized cells in the ovary—and is thought to influence local polyamine levels that affect steroid hormone synthesis and sperm function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Detailed subcellular investigations further reveal that the unique N-terminal determinants of AZIN2 drive its specific targeting to secretory compartments, distinguishing its role from that of AZIN1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Comprehensive tissue mapping has confirmed that AZIN2 expression is particularly high in cells with active vesicular transport and secretory functions – including various neural populations, pulmonary type II pneumocytes, gastric parietal cells, and endocrine islet cells – supporting a role in fine-tuning secretory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Finally, in certain cancers such as adenoid cystic carcinoma, higher AZIN2 expression correlates with a well-differentiated, secretory phenotype and improved patient survival, suggesting that AZIN2 may serve as a favorable prognostic marker in tumors retaining secretory competency."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinzhong Li, Xiang He, He Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvy075"}], "href": "https://doi.org/10.1093/cvr/cvy075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29584819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29584819"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrés J López-Contreras, Carlos López-Garcia, Celia Jiménez-Cervantes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M602840200"}], "href": "https://doi.org/10.1074/jbc.M602840200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16916800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16916800"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kristiina Kanerva, Jani Lappalainen, Laura T Mäkitie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006858"}], "href": "https://doi.org/10.1371/journal.pone.0006858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19718454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19718454"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carlos Acosta-Andrade, Ana Lambertos, José L Urdiales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-016-2230-3"}], "href": "https://doi.org/10.1007/s00726-016-2230-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27084713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27084713"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Andrés J López-Contreras, Bruno Ramos-Molina, Asunción Cremades, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801024200"}], "href": "https://doi.org/10.1074/jbc.M801024200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18508777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18508777"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Andrés J López-Contreras, Bruno Ramos-Molina, Asunción Cremades, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme inhibitor 2: molecular, cellular and physiological aspects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-009-0419-4"}], "href": "https://doi.org/10.1007/s00726-009-0419-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19956990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19956990"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laura T Mäkitie, Kristiina Kanerva, Tuomo Polvikoski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1750-3639.2009.00334.x"}], "href": "https://doi.org/10.1111/j.1750-3639.2009.00334.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19832840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19832840"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kristiina Kanerva, Laura T Mäkitie, Nils Bäck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.02.021"}], "href": "https://doi.org/10.1016/j.yexcr.2010.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20188728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20188728"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Leslie A Sandusky-Beltran, Andrii Kovalenko, Devon S Placides, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI126299"}], "href": "https://doi.org/10.1172/JCI126299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33586680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33586680"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Laura T Mäkitie, Kristiina Kanerva, Anna Sankila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-009-0636-7"}], "href": "https://doi.org/10.1007/s00418-009-0636-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19756694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19756694"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ana Lambertos, Bruno Ramos-Molina, Andrés J López-Contreras, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0209202"}], "href": "https://doi.org/10.1371/journal.pone.0209202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30566531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30566531"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andrés J López-Contreras, Berta L Sánchez-Laorden, Bruno Ramos-Molina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22168"}], "href": "https://doi.org/10.1002/jcb.22168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19449338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19449338"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tiina Rasila, Alexandra Lehtonen, Kristiina Kanerva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0151175"}], "href": "https://doi.org/10.1371/journal.pone.0151175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26963840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26963840"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Carlos López-Garcia, Bruno Ramos-Molina, Ana Lambertos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0069188"}], "href": "https://doi.org/10.1371/journal.pone.0069188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23874910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23874910"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hanna Hämetoja, Leif C Andersson, Antti Mäkitie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "APMIS (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/apm.13158"}], "href": "https://doi.org/10.1111/apm.13158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34046926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34046926"}]}]}]}
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| Synonyms | AZIB1, ODC-P |
| Proteins | AZIN2_HUMAN |
| NCBI Gene ID | 113451 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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AZIN2 has 2,771 functional associations with biological entities spanning 7 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 58 datasets.
Click the + buttons to view associations for AZIN2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of AZIN2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of AZIN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of AZIN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of AZIN2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of AZIN2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with AZIN2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of AZIN2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing AZIN2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing AZIN2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with AZIN2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| CTD Gene-Disease Associations | diseases associated with AZIN2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by AZIN2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with AZIN2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with AZIN2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with AZIN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with AZIN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with AZIN2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of AZIN2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of AZIN2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving AZIN2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving AZIN2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving AZIN2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing AZIN2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing AZIN2 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing AZIN2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by AZIN2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by AZIN2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by AZIN2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of AZIN2 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of AZIN2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of AZIN2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of AZIN2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with AZIN2 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with AZIN2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| HumanCyc Pathways | pathways involving AZIN2 protein from the HumanCyc Pathways dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for AZIN2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of AZIN2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of AZIN2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with AZIN2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain AZIN2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by AZIN2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting AZIN2 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by AZIN2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MW Enzyme Metabolite Associations | interacting metabolites for AZIN2 protein from the MW Gene Metabolite Associations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of AZIN2 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving AZIN2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving AZIN2 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving AZIN2 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving AZIN2 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of AZIN2 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of AZIN2 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of AZIN2 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of AZIN2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of AZIN2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of AZIN2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of AZIN2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of AZIN2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with AZIN2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
