B3GNT2 Gene

HGNC Family	Glycosyltransferases
Name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Description	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n B3GNT2 is a β1,3‐N‐acetylglucosaminyltransferase that plays a central role in the biosynthesis of poly–N‐acetyllactosamine (polyLacNAc) chains on N‐glycans. Functional studies using B3gnt2‐deficient mice have demonstrated that loss of this enzyme drastically reduces polyLacNAc structures on key immune receptors (for example, CD28 and CD19), leading to an abnormally hyperresponsive lymphocyte phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Structural and kinetic analyses of human B3GNT2 have further established that it is the major polyLacNAc synthase, detailing its substrate recognition and catalytic mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the nervous system, B3GNT2-mediated glycosylation is crucial for proper modification of proteins such as adenylyl cyclase 3 in the olfactory epithelium; loss of B3GNT2 results in impaired cAMP generation and altered axon guidance, as evidenced by studies in knockout mice."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In oncological contexts, aberrant expression or genetic alterations of B3GNT2 have been linked to dysregulated glycosylation patterns that modify the function of receptors such as EGFR. In hepatocellular and esophageal carcinomas, for instance, altered B3GNT2 expression reconfigures polylactosamine decoration on EGFR and impacts downstream signaling pathways (notably JAK/STAT), thereby promoting tumor progression and correlating with a poorer prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Furthermore, genomic studies have identified copy number alterations encompassing the B3GNT2 gene—such as microduplications at 2p15—that may contribute to developmental anomalies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of B3GNT2 in regulating glycan structures that are essential for immune modulation, neural signal transduction, and the pathogenesis of certain malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akira Togayachi, Yuko Kozono, Atsushi Kuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta3GnT2 (B3GNT2), a major polylactosamine synthase: analysis of B3GNT2-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Methods Enzymol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0076-6879(10)79011-X"}], "href": "https://doi.org/10.1016/S0076-6879(10"}, {"type": "t", "text": "79011-X) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20816167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20816167"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yue Hao, Amandine Créquer-Grandhomme, Noelle Javier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structures and mechanism of human glycosyltransferase β1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important player in immune homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015306"}], "href": "https://doi.org/10.1074/jbc.RA120.015306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33158990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33158990"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Timothy R Henion, Ashley A Faden, Thomas K Knott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0224-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.0224-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21525298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21525298"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas K Knott, Pasil A Madany, Ashley A Faden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neural Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1749-8104-7-17"}], "href": "https://doi.org/10.1186/1749-8104-7-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22559903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22559903"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mahdi Mahmoudi, Masoud Garshasbi, Amir Ashraf-Ganjouei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between rs6759298 and Ankylosing Spondylitis in Iranian Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Avicenna J Med Biotechnol (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30090213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30090213"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhiguo Luo, Qing Hu, Yuanhui Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-022-00306-y"}], "href": "https://doi.org/10.1186/s11658-022-00306-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35073841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35073841"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hao Qiu, Wei-Ming Duan, Jie Shu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.24.10875"}], "href": "https://doi.org/10.7314/apjcp.2014.15.24.10875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25605193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25605193"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chih-Ping Chen, Schu-Rern Chern, Peih-Shan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prenatal diagnosis of familial 2p15 microduplication associated with pulmonary artery stenosis, single umbilical artery and left foot postaxial polydactyly on fetal ultrasound."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Taiwan J Obstet Gynecol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tjog.2020.11.025"}], "href": "https://doi.org/10.1016/j.tjog.2020.11.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33494994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33494994"}]}]}]}
Synonyms	BGNT-2, B3GN-T2, B3GNT, beta3Gn-T1, B3GNT1, BETA3GNT, 3-Gn-T1, beta-1, B3GNT-2, BGNT2, 3-Gn-T2, beta3Gn-T2
Proteins	B3GN2_HUMAN
NCBI Gene ID	10678
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

B3GNT2 has 6,625 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for B3GNT2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

B3GNT2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by B3GNT2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of B3GNT2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of B3GNT2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of B3GNT2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of B3GNT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of B3GNT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of B3GNT2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of B3GNT2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of B3GNT2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of B3GNT2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of B3GNT2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of B3GNT2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with B3GNT2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with B3GNT2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of B3GNT2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of B3GNT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of B3GNT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of B3GNT2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing B3GNT2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of B3GNT2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing B3GNT2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with B3GNT2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of B3GNT2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with B3GNT2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with B3GNT2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with B3GNT2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of B3GNT2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by B3GNT2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with B3GNT2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with B3GNT2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with B3GNT2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at B3GNT2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of B3GNT2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of B3GNT2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing B3GNT2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of B3GNT2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with B3GNT2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing B3GNT2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of B3GNT2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of B3GNT2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.