BCL2L2 Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	BCL2-like 2
Description	This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>BCL2L2/Bcl‐w Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n BCL2L2, which encodes the anti‐apoptotic protein Bcl‐w, is a pivotal member of the Bcl‐2 family that governs cell survival in diverse biological contexts. By sequestering pro‐apoptotic factors, Bcl‐w thwarts mitochondrial outer membrane permeabilization and thereby prevents caspase activation and apoptosis. In several settings, elevated Bcl‐w levels promote cell survival; for example, senescent cells upregulate Bcl‐w to resist apoptotic signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and pericyte‐derived signals in tumor endothelial cells induce its expression to confer protection from cytotoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, downregulation of Bcl‐w sensitizes cells to apoptosis. In neurons, for instance, amyloid‐β‐induced reductions in Bcl‐w contribute to mitochondrial dysfunction and cell death"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while in various cancers the expression of Bcl‐w is modulated via multiple microRNAs. Reduced levels of miR‑205 in advanced prostate cancer lead to an increase in BCL2L2 expression and promote chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and targeting by miR‑125b, miR‑122, miR‑133B, and miR‑335 has been shown to decrease Bcl‐w levels, thereby increasing the susceptibility of malignant cells to apoptotic stimuli."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " Furthermore, outside transcriptional and post‐transcriptional regulation, the intrinsic structural features of Bcl‐w critically modulate its function; its C‐terminal residues can occlude the hydrophobic BH3–binding groove, thereby controlling access of pro‐apoptotic ligands."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these studies highlight the central role of Bcl‐w as a regulator of cell fate. Its differential regulation, whether through microRNAs, receptor‐mediated signaling, or structural modulation, not only defines sensitivity to apoptotic cues in normal cells but also contributes to disease pathogenesis and therapeutic resistance, making Bcl‐w a promising target for intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11190"}], "href": "https://doi.org/10.1038/ncomms11190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27048913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27048913"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marcela Franco, Pernilla Roswall, Eliane Cortez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-01-331694"}], "href": "https://doi.org/10.1182/blood-2011-01-331694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21778339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21778339"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingzhong Yao, Thuy-Vi V Nguyen, Christian J Pike "}, {"type": "b", "children": [{"type": "t", "text": "Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4736-04.2005"}], "href": "https://doi.org/10.1523/JNEUROSCI.4736-04.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15689551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15689551"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y H Kim, L Girard, C P Giacomini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208997"}], "href": "https://doi.org/10.1038/sj.onc.1208997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16116477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16116477"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Laura Gramantieri, Francesca Fornari, Manuela Ferracin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-09-0092"}], "href": "https://doi.org/10.1158/1078-0432.CCR-09-0092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19671867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19671867"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Cliff Ji-Fan Lin, Hong-Yi Gong, Hung-Chia Tseng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.07.154"}], "href": "https://doi.org/10.1016/j.bbrc.2008.07.154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18692484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18692484"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Melissa Crawford, Kara Batte, Lianbo Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.07.143"}], "href": "https://doi.org/10.1016/j.bbrc.2009.07.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19654003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19654003"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Xu, F Zhao, Z Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.340"}], "href": "https://doi.org/10.1038/onc.2011.340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21822301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21822301"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Susmit Suvas, Vinod Singh, Sudhir Sahdev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M105902200"}], "href": "https://doi.org/10.1074/jbc.M105902200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11726649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11726649"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mark G Hinds, Martin Lackmann, Gretchen L Skea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg144"}], "href": "https://doi.org/10.1093/emboj/cdg144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12660157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12660157"}]}]}]}
Synonyms	BCL2-L-2, BCL-W, BCLW, PPP1R51
Proteins	B2CL2_HUMAN
NCBI Gene ID	599
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BCL2L2 has 6,812 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for BCL2L2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BCL2L2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by BCL2L2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCL2L2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCL2L2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BCL2L2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BCL2L2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BCL2L2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BCL2L2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BCL2L2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BCL2L2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BCL2L2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of BCL2L2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BCL2L2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BCL2L2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with BCL2L2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BCL2L2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BCL2L2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BCL2L2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BCL2L2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BCL2L2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BCL2L2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BCL2L2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BCL2L2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BCL2L2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BCL2L2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BCL2L2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BCL2L2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BCL2L2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of BCL2L2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BCL2L2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with BCL2L2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BCL2L2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BCL2L2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BCL2L2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BCL2L2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for BCL2L2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BCL2L2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BCL2L2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BCL2L2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BCL2L2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with BCL2L2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.