{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BIVM (basic, immunoglobulin‐like variable motif–containing) is an evolutionarily conserved, ubiquitously expressed housekeeping gene that localizes to human chromosome 13q32–q33. Initially identified by its conserved immunoglobulin‐like motifs and a predicted basic protein structure (1), comparative genomic studies have revealed that BIVM is conserved throughout deuterostomes—with no clear homologs in several other lineages—underscoring its essential cellular role. In addition, recent phylogenetic profiling and experimental localization analyses have demonstrated that BIVM is present at the cilia/basal body, suggesting a potential role in ciliary assembly or function (3). Beyond its basic cellular role, transcriptional and genome‐wide association studies indicate that BIVM may be involved in diverse pathological processes. For instance, differential gene expression analyses in children exposed to persistent organic pollutants have identified BIVM as one of a set of genes linked to disorders involving connective tissue, skeletal muscle, and neurological function (2). In the context of cancer, a single nucleotide polymorphism in the BIVM–ERCC5 locus has been associated with an increased risk of breast cancer, suggesting possible involvement in DNA repair or genomic maintenance pathways (4). Moreover, genetic studies in bipolar disorder have highlighted nominal associations between variants in the broader LOC93081–KDELC1–BIVM region and disease susceptibility (5). Collectively, these findings point to a multifunctional role for BIVM: while it serves as a housekeeping gene essential for baseline cellular operation, its localization to ciliary structures and association with disease‐related genomic variants suggest that it may contribute to processes as diverse as ciliary function, DNA repair, and complex disease susceptibility.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "(2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "(3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "(4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "(5)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jeffrey A Yoder, Noel A Hawke, Donna D Eason, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/geno.2002.6768"}], "href": "https://doi.org/10.1006/geno.2002.6768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12036287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12036287"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Partha Sarathi Mitra, Somiranjan Ghosh, Shizhu Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Int (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.envint.2011.09.003"}], "href": "https://doi.org/10.1016/j.envint.2011.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22208759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22208759"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yannis Nevers, Megana K Prasad, Laetitia Poidevin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Evol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molbev/msx146"}], "href": "https://doi.org/10.1093/molbev/msx146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28460059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28460059"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Ge, Hongliang Liu, Danwen Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.32371"}], "href": "https://doi.org/10.1002/ijc.32371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31026346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31026346"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dilberto O Ferraren, Chunyu Liu, Judith A Badner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30121"}], "href": "https://doi.org/10.1002/ajmg.b.30121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15635705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15635705"}]}]}]}