{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nBLACE was originally identified by a representational difference analysis aimed at distinguishing gene expression profiles between acute leukemia cells and normal hematopoietic tissues. The gene, mapped to region 7q36, encodes a major 5.3‐kb transcript along with several alternatively spliced minor transcripts. Its discovery in a B cell acute lymphoblastic leukemia (B‐ALL) cell line bearing two Philadelphia chromosomes highlights its unique expression profile among hematological malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "BLACE shows significant expression in the bone marrow samples of patients with B cell acute lymphoblastic leukemia, whereas its expression is minimal or absent in other hematological cancers, normal tissues, and solid tumors. This restricted expression pattern suggests that BLACE may serve as a specific molecular marker for B‐ALL, potentially offering insights into the underlying pathogenesis of this leukemia subtype and providing a basis for its future diagnostic or therapeutic targeting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexandra Vialle-Castellano, Sandra Laduron, Etienne De Plaen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A gene expressed exclusively in acute B lymphoblastic leukemias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0888-7543(03)00209-x"}], "href": "https://doi.org/10.1016/s0888-7543(03"}, {"type": "t", "text": "00209-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14667812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14667812"}]}]}]}