{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BORCS6, a subunit of the BORC complex, plays a multifaceted role in lysosomal function and cellular homeostasis. As part of the BORC machinery that promotes lysosome dispersal via recruitment of the Arl8 GTPase and kinesin motors, BORCS6 is integral for maintaining proper lysosome positioning and dynamics. Notably, loss of BORCS6 disrupts the normal morphology of specialized lysosome‐related organelles; for instance, in alveolar epithelial type II cells the genetic ablation of BORCS6 causes an enlargement of lamellar bodies, implicating a LRRK2–BORCS6 pathway in the regulation of lysosomal exocytosis and surfactant secretion (1). In addition, BORCS6 is synonymous with the Ragulator‐interacting protein C17orf59 and has been shown to bind to Ragulator on the lysosomal membrane, where it competitively interferes with the association between Rag GTPases and Ragulator. This interference modulates amino acid–dependent activation of mTORC1 by impairing the recruitment of mTOR to lysosomes, thereby influencing cellular growth and nutrient signaling (2,3,4). Collectively, these findings define BORCS6 as a critical regulator linking lysosome positioning and function with mTORC1 signaling, ultimately contributing to diverse processes such as membrane trafficking, autophagosome–lysosome fusion, and cellular metabolic homeostasis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "\n <br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br>\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "<br>\n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "<br>\n (4)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Miho Araki, Kyohei Ito, Sho Takatori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddab146"}], "href": "https://doi.org/10.1093/hmg/ddab146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34077533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34077533"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maike Becker, Isabelle Serr, Victoria K Salb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short-term cold exposure supports human Treg induction in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2019.08.002"}], "href": "https://doi.org/10.1016/j.molmet.2019.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31427184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31427184"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lawrence D Schweitzer, William C Comb, Liron Bar-Peled, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.07.052"}], "href": "https://doi.org/10.1016/j.celrep.2015.07.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26299971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26299971"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tianlong Zhang, Rong Wang, Zhijing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01567-4"}], "href": "https://doi.org/10.1038/s41467-017-01567-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29123114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29123114"}]}]}]}