BRD4 Gene

Name	bromodomain containing 4
Description	The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n BRD4 is a multifunctional epigenetic reader and transcriptional co‐regulator that plays a central role in interpreting acetylated chromatin marks and orchestrating gene expression programs. By using its tandem bromodomains, BRD4 selectively binds di‐ and tetra–acetylated histones and remains associated with chromatin throughout the cell cycle, thereby “bookmarking” active genes during mitosis for rapid reactivation in G1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In interphase, BRD4 recruits positive transcription elongation factor b (P‐TEFb) to promoters and enhancers, stimulating the phosphorylation of the RNA polymerase II C-terminal domain to overcome promoter–proximal pausing and support productive transcript elongation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " This function underlies its capacity to sustain oncogenic transcriptional programs, as seen by its role in maintaining MYC expression in acute myeloid leukemia, neuroblastoma, and MYC-amplified medulloblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in elongation, BRD4 interacts with and modulates the activity of key DNA-binding factors. Its binding to acetylated RelA, for instance, enhances NF-κB–dependent inflammatory gene transcription and stability of the nuclear NF-κB complex"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while phosphorylation–regulated interactions with p53 provide a mechanism for gene-specific recruitment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " BRD4 also functions as a coactivator by engaging with master regulators such as Twist in basal-like breast cancer and with components of leukemogenic transcriptional complexes, thus reinforcing lineage-specific and oncogenic transcriptional networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent studies have further expanded the functional repertoire of BRD4 by revealing its intrinsic histone acetyltransferase activity, which targets residues critical for nucleosome stability and thereby promotes chromatin decompaction and transcriptional activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, BRD4’s participation in the formation and regulation of super-enhancers, its role in mediating pause release at distal regulatory elements and anti-pause enhancers, and its integration into higher-order chromatin structures collectively contribute to both the maintenance of oncogenic transcriptional programs and the execution of tumor-suppressive processes such as senescence-associated secretory phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, by stably associating with viral factors (for example, in papillomavirus E2 and HIV-1 Tat complexes), BRD4 facilitates viral genome tethering and robust transcriptional elongation, underscoring its versatility in both normal and pathologic settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, these multifaceted roles of BRD4—from reading histone acetylation and recruiting elongation factors to remodeling chromatin structure and interfacing with oncogenic and inflammatory signaling pathways—underscore its central importance in gene regulation and validate it as a promising therapeutic target as evidenced by the efficacy of BET inhibitors in preclinical models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anup Dey, Farideh Chitsaz, Asim Abbasi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1433065100"}], "href": "https://doi.org/10.1073/pnas.1433065100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12840145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12840145"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anup Dey, Akira Nishiyama, Tatiana Karpova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0380"}], "href": "https://doi.org/10.1091/mbc.e09-05-0380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19812244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19812244"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dwayne A Bisgrove, Tokameh Mahmoudi, Peter Henklein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0705053104"}], "href": "https://doi.org/10.1073/pnas.0705053104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17690245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17690245"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tomohiko Kanno, Yuka Kanno, Gary LeRoy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2912"}], "href": "https://doi.org/10.1038/nsmb.2912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25383670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25383670"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Johannes Zuber, Junwei Shi, Eric Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10334"}], "href": "https://doi.org/10.1038/nature10334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21814200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21814200"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alexandre Puissant, Stacey M Frumm, Gabriela Alexe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting MYCN in neuroblastoma by BET bromodomain inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-12-0418"}], "href": "https://doi.org/10.1158/2159-8290.CD-12-0418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23430699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23430699"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bo Huang, Xiao-Dong Yang, Ming-Ming Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01365-08"}], "href": "https://doi.org/10.1128/MCB.01365-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19103749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19103749"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Z Zou, B Huang, X Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.179"}], "href": "https://doi.org/10.1038/onc.2013.179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23686307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23686307"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shwu-Yuan Wu, A-Young Lee, Hsien-Tsung Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.12.006"}], "href": "https://doi.org/10.1016/j.molcel.2012.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23317504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23317504"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jian Shi, Yifan Wang, Lei Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2014.01.028"}], "href": "https://doi.org/10.1016/j.ccr.2014.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24525235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24525235"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ballachanda N Devaiah, Brian A Lewis, Natasha Cherman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1120422109"}], "href": "https://doi.org/10.1073/pnas.1120422109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22509028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22509028"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ballachanda N Devaiah, Chanelle Case-Borden, Anne Gegonne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3228"}], "href": "https://doi.org/10.1038/nsmb.3228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27159561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27159561"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nilgun Tasdemir, Ana Banito, Jae-Seok Roe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-16-0217"}], "href": "https://doi.org/10.1158/2159-8290.CD-16-0217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27099234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27099234"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wen Liu, Qi Ma, Kaki Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.10.056"}], "href": "https://doi.org/10.1016/j.cell.2013.10.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24360279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24360279"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jianxin You, Jennie L Croyle, Akiko Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(04)00402-7"}], "href": "https://doi.org/10.1016/s0092-8674(04"}, {"type": "t", "text": "00402-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15109495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15109495"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Nanhai He, Min Liu, Joanne Hsu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3613"}], "href": "https://doi.org/10.1038/nm.3613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24973920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24973920"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Francesca Zanconato, Giusy Battilana, Mattia Forcato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-018-0158-8"}], "href": "https://doi.org/10.1038/s41591-018-0158-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30224758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30224758"}]}]}]}
Synonyms	HUNK1, HUNKI
Proteins	BRD4_HUMAN
NCBI Gene ID	23476
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BRD4 has 10,102 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for BRD4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BRD4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by BRD4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BRD4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BRD4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BRD4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BRD4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BRD4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BRD4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BRD4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BRD4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BRD4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with BRD4 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BRD4 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with BRD4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BRD4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BRD4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BRD4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BRD4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BRD4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BRD4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing BRD4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing BRD4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BRD4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BRD4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing BRD4 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of BRD4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BRD4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BRD4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BRD4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving BRD4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BRD4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BRD4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BRD4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BRD4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BRD4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BRD4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BRD4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BRD4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of BRD4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with BRD4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing BRD4 from the GeneSigDB Published Gene Signatures dataset.