BSG Gene

HGNC Family	Immunoglobulin superfamily domain containing, Blood group antigens, CD molecules (CD)
Name	basigin (Ok blood group)
Description	The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Basigin (BSG), also known as CD147 or EMMPRIN, is a multifunctional transmembrane glycoprotein that plays critical roles in diverse physiological and pathological processes. As a key chaperone for monocarboxylate transporters, BSG facilitates the cell surface integration and activity of MCT1 and MCT4, thereby regulating lactate and pyruvate export and supporting glycolytic metabolism and tumor energetics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, BSG is instrumental in remodeling the extracellular matrix by inducing matrix metalloproteinase production in both tumor and surrounding stromal cells, a function that contributes to enhanced cancer invasion, metastasis, and overall tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the realm of infectious disease, BSG serves as the critical erythrocyte receptor for Plasmodium falciparum’s PfRh5 ligand, an interaction that is essential for the parasite’s invasion of red blood cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the retina, the BSG1 isoform acts as the receptor for rod-derived cone viability factor, thereby coupling with the glucose transporter GLUT1 to promote increased glucose uptake and protect cone photoreceptors from degeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " BSG also functions as a receptor for extracellular cyclophilins, mediating signaling events such as ERK activation that contribute to inflammatory cell recruitment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Although early studies posited that BSG might serve as an alternate entry receptor for SARS-CoV-2, more recent investigations have failed to demonstrate a functional interaction, questioning its role in COVID-19 pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Finally, BSG is implicated in reprogramming tumor lipid metabolism—for example, in hepatocellular carcinoma it modulates lipogenic pathways and suppresses fatty acid β-oxidation, thereby contributing to cancer cell proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Renaud Le Floch, Johanna Chiche, Ibtissam Marchiq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1106123108"}], "href": "https://doi.org/10.1073/pnas.1106123108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21930917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21930917"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Candice Sun Hong, Nicholas A Graham, Wen Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.01.057"}], "href": "https://doi.org/10.1016/j.celrep.2016.01.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26876179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26876179"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takuro Kanekura, Xiang Chen, Tamotsu Kanzaki "}, {"type": "b", "children": [{"type": "t", "text": "Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.10390"}], "href": "https://doi.org/10.1002/ijc.10390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11992541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11992541"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi Tang, Marian T Nakada, Prabakaran Kesavan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-04-3605"}], "href": "https://doi.org/10.1158/0008-5472.CAN-04-3605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15833850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15833850"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cécile Crosnier, Leyla Y Bustamante, S Josefin Bartholdson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10606"}], "href": "https://doi.org/10.1038/nature10606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22080952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22080952"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Najate Aït-Ali, Ram Fridlich, Géraldine Millet-Puel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.03.023"}], "href": "https://doi.org/10.1016/j.cell.2015.03.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25957687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25957687"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vyacheslav Yurchenko, Gabriele Zybarth, Matthew O'Connor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Active site residues of cyclophilin A are crucial for its signaling activity via CD147."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201593200"}], "href": "https://doi.org/10.1074/jbc.M201593200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11943775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11943775"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Urszula Radzikowska, Mei Ding, Ge Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/all.14429"}], "href": "https://doi.org/10.1111/all.14429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32496587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32496587"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Natalia Zamorano Cuervo, Nathalie Grandvaux "}, {"type": "b", "children": [{"type": "t", "text": "ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.61390"}], "href": "https://doi.org/10.7554/eLife.61390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33164751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33164751"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jarrod Shilts, Thomas W M Crozier, Edward J D Greenwood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-80464-1"}], "href": "https://doi.org/10.1038/s41598-020-80464-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33432067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33432067"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jibin Li, Qichao Huang, Xiaoyu Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2015.07.039"}], "href": "https://doi.org/10.1016/j.jhep.2015.07.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26282231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26282231"}]}]}]}
Synonyms	5F7, M6, TCSF, OK, SLC7A11, CD147, EMMPRIN, EMPRIN
Proteins	BASI_HUMAN
NCBI Gene ID	682
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

BSG has 13,576 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for BSG from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

BSG Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BSG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of BSG gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of BSG gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of BSG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of BSG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of BSG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of BSG gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BSG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of BSG gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of BSG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of BSG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with BSG protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with BSG gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSG gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of BSG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of BSG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with BSG gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of BSG gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing BSG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing BSG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with BSG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with BSG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing BSG protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with BSG gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with BSG gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with BSG gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of BSG protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by BSG gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with BSG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with BSG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with BSG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with BSG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at BSG gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of BSG gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of BSG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing BSG from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with BSG gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of BSG gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with BSG gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing BSG from the GeneSigDB Published Gene Signatures dataset.