| Name | chromosome 11 open reading frame 98 |
| Description | This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:79081), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017] |
| Summary |
{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary Abstract</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted that many microproteins encoded by small open reading frames (sORFs) play crucial roles in fundamental cellular processes. In one study, an advanced in situ proximity tagging approach using engineered ascorbate peroxidase 2 (APEX) was applied to the uncharacterized microprotein C11orf98, revealing that it interacts with key nucleolar proteins—nucleophosmin and nucleolin—suggesting a role in nucleolar activities such as ribosome biogenesis and cellular stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This finding complements broader integrative analyses that have uncovered a wealth of small proteins encoded within transcripts previously classified as noncoding, underscoring the diverse physiological implications of the micropeptidome, including developmental processes and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these works emphasize the power of novel proteomic methods in discovering microprotein-protein interactions and advancing our understanding of the important, yet often overlooked, functional landscape of sORF-encoded microproteins.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qian Chu, Annie Rathore, Jolene K Diedrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Microprotein-Protein Interactions via APEX Tagging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.7b00265"}], "href": "https://doi.org/10.1021/acs.biochem.7b00265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28589727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28589727"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fouzia Yeasmin, Tetsushi Yada, Nobuyoshi Akimitsu "}, {"type": "b", "children": [{"type": "t", "text": "Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2018.00144"}], "href": "https://doi.org/10.3389/fgene.2018.00144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29922328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29922328"}]}]}]}
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| Synonyms | C11orf98 |
| Proteins | CK098_HUMAN |
| NCBI Gene ID | 102288414 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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C11ORF98 has 735 functional associations with biological entities spanning 4 categories (chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.
Click the + buttons to view associations for C11ORF98 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of C11ORF98 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of C11ORF98 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of C11ORF98 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with C11ORF98 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with C11ORF98 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of C11ORF98 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of C11ORF98 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of C11ORF98 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of C11ORF98 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with C11ORF98 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |