{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nC19orf84 is an evolutionarily conserved protein that plays an essential role in orchestrating piRNA‐directed de novo DNA methylation, a key epigenetic process required for transposon silencing in the male germ line. In fetal gonocytes, C19orf84 interacts directly with SPOCD1 and associates with the DNA methyltransferase DNMT3C to facilitate the methylation of young, active transposons. This interaction is critical for establishing proper transposon repression, and loss‐of‐function variants affecting SPOCD1 (and consequently its interaction with C19orf84) result in defective transposon silencing and lead to male infertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThus, C19orf84 emerges as an indispensable component of the piRNA pathway, mediating the physical connection between transposon‐targeting factors and the de novo methylation machinery. Its function is crucial for maintaining genome stability in the male germ line and ensuring proper spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ansgar Zoch, Gabriela Konieczny, Tania Auchynnikava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2024.01.014"}], "href": "https://doi.org/10.1016/j.molcel.2024.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38359823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38359823"}]}]}]}