C1QA Gene

HGNC Family	Complement system
Name	complement component 1, q subcomponent, A chain
Description	This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Complement C1q – and specifically its A‐chain (C1QA) – is emerging as a multifunctional regulator whose roles extend far beyond its classical function as the recognition subunit of the complement cascade. In its canonical role, C1q binds to a wide range of ligands – including aggregated immunoglobulins, pentraxins, and apoptotic cells – to initiate and modulate complement activation and ensuing inflammatory processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the central nervous system, microglia are the dominant local source of C1q, where it plays a critical role in synaptic pruning during development and in disease; however, aberrant or excessive C1q‐mediated synapse elimination has been linked to neurodegeneration in aging, Alzheimer’s disease, glaucoma, and frontotemporal dementia models – with genetic deletion or pharmacologic inhibition proving protective in experimental systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, C1q can activate non‐complement pathways such as canonical Wnt signaling, thereby influencing tissue regeneration and aging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Outside the central nervous system, locally produced C1q has been shown to regulate peripheral immune functions and tissue remodeling. In wound healing, for example, C1q is deposited in the healing skin, where it enhances vascular endothelial proliferation, migration, and tube formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Similarly, C1q modulation of type 2 macrophage activation can influence tissue repair and liver regeneration—although dysregulation in this context may also contribute to fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In cancer, locally synthesized C1q appears to promote tumor cell adhesion, migration, and proliferation, thereby facilitating enhanced vascularization and metastasis, while polymorphisms in the C1qA gene have been associated with differential responses to therapeutic antibodies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, by binding to apoptotic cells, C1q facilitates their clearance by macrophages—a key mechanism in maintaining self‐tolerance and preventing autoimmunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " In the context of liver injury, particularly under ethanol exposure, C1q deposition on apoptotic Kupffer cells triggers complement activation that contributes to hepatocellular damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore that C1q – with its modular globular head enabling diverse ligand interactions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "– is a versatile mediator of immune homeostasis, synaptic remodeling, tissue repair, and cell signaling. Dysregulation of C1q functions has profound implications in neurodegenerative diseases, cancer progression, and inflammatory disorders, highlighting its potential as a therapeutic target in a variety of pathological conditions ("}, {"type": "b", "children": [{"type": "t", "text": "(1–17)"}]}, {"type": "t", "text": ").\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alma J Nauta, Barbara Bottazzi, Alberto Mantovani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical and functional characterization of the interaction between pentraxin 3 and C1q."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/immu.200310022"}], "href": "https://doi.org/10.1002/immu.200310022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12645945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12645945"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nicole M Thielens, Francesco Tedesco, Suzanne S Bohlson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C1q: A fresh look upon an old molecule."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2017.05.025"}], "href": "https://doi.org/10.1016/j.molimm.2017.05.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28601358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28601358"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lubka T Roumenina, Marieta M Ruseva, Alexandra Zlatarova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi052646f"}], "href": "https://doi.org/10.1021/bi052646f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16566583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16566583"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hansen Lui, Jiasheng Zhang, Stefanie R Makinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.04.001"}], "href": "https://doi.org/10.1016/j.cell.2016.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27114033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27114033"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria I Fonseca, Shu-Hui Chu, Michael X Hernandez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12974-017-0814-9"}], "href": "https://doi.org/10.1186/s12974-017-0814-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28264694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28264694"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pete A Williams, James R Tribble, Keating W Pepper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurodegener (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13024-016-0091-6"}], "href": "https://doi.org/10.1186/s13024-016-0091-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27048300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27048300"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Colleen A Mangold, Benjamin Wronowski, Mei Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12974-017-0920-8"}], "href": "https://doi.org/10.1186/s12974-017-0920-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28732515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28732515"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ileana Soto, Leah C Graham, Hannah J Richter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1002279"}], "href": "https://doi.org/10.1371/journal.pbio.1002279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26512759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26512759"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Julia Reichwald, Simone Danner, Karl-Heinz Wiederhold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of complement system components during aging and amyloid deposition in APP transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1742-2094-6-35"}], "href": "https://doi.org/10.1186/1742-2094-6-35"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19917141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19917141"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Atsuhiko T Naito, Tomokazu Sumida, Seitaro Nomura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.03.047"}], "href": "https://doi.org/10.1016/j.cell.2012.03.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22682250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22682250"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Fleur Bossi, Claudio Tripodo, Lucia Rizzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C1q as a unique player in angiogenesis with therapeutic implication in wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1311968111"}], "href": "https://doi.org/10.1073/pnas.1311968111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24591625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24591625"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Carlos M Minutti, Lucy H Jackson-Jones, Belén García-Fojeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaj2067"}], "href": "https://doi.org/10.1126/science.aaj2067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28495878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28495878"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Roberta Bulla, Claudio Tripodo, Damiano Rami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10346"}], "href": "https://doi.org/10.1038/ncomms10346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26831747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26831747"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Emilian Racila, Brian K Link, Wen-Kai Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-0745"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-0745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18927313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18927313"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Qunying Hong, Chun-I Sze, Sing-Ru Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005755"}], "href": "https://doi.org/10.1371/journal.pone.0005755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19484134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19484134"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lata Mukundan, Justin I Odegaard, Christine R Morel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2048"}], "href": "https://doi.org/10.1038/nm.2048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19838202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19838202"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jessica I Cohen, Sanjoy Roychowdhury, Megan R McMullen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.04.041"}], "href": "https://doi.org/10.1053/j.gastro.2010.04.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20416309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20416309"}]}]}]}
Proteins	C1QA_HUMAN
NCBI Gene ID	712
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

C1QA has 7,465 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for C1QA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

C1QA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by C1QA gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of C1QA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of C1QA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of C1QA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of C1QA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of C1QA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of C1QA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving C1QA protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of C1QA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of C1QA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of C1QA gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of C1QA gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of C1QA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of C1QA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with C1QA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of C1QA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of C1QA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of C1QA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with C1QA gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with C1QA gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of C1QA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing C1QA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing C1QA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing C1QA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with C1QA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with C1QA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of C1QA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with C1QA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with C1QA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with C1QA gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by C1QA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving C1QA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with C1QA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with C1QA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with C1QA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with C1QA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for C1QA protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at C1QA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of C1QA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of C1QA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.