{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n C1QTNF7, a member of the C1q/tumor necrosis factor‐related protein (CTRP) family, appears to function as a multifaceted secreted glycoprotein with roles spanning metabolic regulation, neural/behavioral processes, and immune responses. In neuropsychiatric research, genome‐wide association analyses have identified variants in the C1QTNF7 gene that are significantly associated with conduct disorder symptomatology, suggesting a potential influence on neurodevelopment or behavioral regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In metabolic studies, the expression and circulating levels of C1QTNF7 are dynamically regulated in scenarios of obesity, insulin resistance, and metabolic syndrome. Elevated levels of this protein are observed in obese individuals and correlate positively with parameters such as body mass index, glucose, insulin, and triglyceride levels; moreover, its modulation during glucose tolerance or lipid‐infusion tests supports a role in insulin action and overall metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Beyond these functions, recent genome‐wide CRISPR/Cas screens have identified C1QTNF7 among a set of host factors required for SARS‑CoV‑2 replication, indicating its potential involvement in virus–host interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, investigations into neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) have revealed that mRNA levels of C1QTNF7 are significantly reduced in affected regions of the spinal cord and frontal cortex, implicating its dysregulation in the altered inflammatory milieu characteristic of such disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Comparative transcriptomic studies in non‐mammalian species have also demonstrated tissue‐specific expression patterns—for instance, in red‑lip mullet, where C1QTNF7 is predominantly expressed in the stomach and is responsive to immune challenges—supporting an ancillary immunomodulatory role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, genomic analyses indicate that regulatory elements such as SVA transposable elements can influence the transcript isoforms of C1QTNF7, which may contribute to its tissue‑specific regulation and functional diversity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the multifaceted role of C1QTNF7 in modulating metabolic and inflammatory pathways. Its regulation in metabolic disorders, potential impact on neural development or behavior, and involvement as a host factor in viral infections position C1QTNF7 as both a promising biomarker and a potential therapeutic target across a spectrum of metabolic, neuropsychiatric, immune, and infectious diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D M Dick, F Aliev, R F Krueger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of conduct disorder symptomatology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2010.73"}], "href": "https://doi.org/10.1038/mp.2010.73"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20585324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20585324"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pia S Petersen, Xia Lei, Risa M Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00344.2016"}], "href": "https://doi.org/10.1152/ajpendo.00344.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28223291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28223291"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kejia Li, Zerong Liang, Weiwei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross-Sectional and Intervention Studies In "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Vivo"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and In "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/6877609"}], "href": "https://doi.org/10.1155/2022/6877609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35368863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35368863"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenjing Hu, Bin Zhan, Qinge Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2021.774309"}], "href": "https://doi.org/10.3389/fendo.2021.774309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34867822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34867822"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sneh Lata, Ritu Mishra, Ravi P Arya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2021.167403"}], "href": "https://doi.org/10.1016/j.jmb.2021.167403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34914966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34914966"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sara Berjaoui, Mónica Povedano, Paula Garcia-Esparcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complex Inflammation mRNA-Related Response in ALS Is Region Dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neural Plast (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/573784"}], "href": "https://doi.org/10.1155/2015/573784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26301107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26301107"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "W K M Omeka, D S Liyanage, Thanthrige Thiunuwan Priyathilaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of four C1q/TNF-related proteins (CTRPs) from red-lip mullet (Liza haematocheila) and their transcriptional modulation in response to bacterial and pathogen-associated molecular pattern stimuli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fish Shellfish Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fsi.2018.09.078"}], "href": "https://doi.org/10.1016/j.fsi.2018.09.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30287348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30287348"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yun-Jeong Kwon, Yuri Choi, Jungwoo Eo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and Expression Analyses of SVA Elements in Relation to Functional Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics Inform (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5808/GI.2013.11.3.142"}], "href": "https://doi.org/10.5808/GI.2013.11.3.142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24124410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24124410"}]}]}]}