C21ORF140 Gene

Name chromosome 21 open reading frame 140
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent findings indicate that treatment with moringin – a bioactive isothiocyanate extracted from Moringa oleifera – modulates several cellular pathways that include regulation of the C21orf140 gene product."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise biological role of C21orf140 remains to be fully elucidated, the study suggests that its modulation by moringin may contribute to the regulation of intracellular signaling cascades involved in anti‐inflammatory, antioxidant, and potentially neuroprotective responses. In this context, C21orf140 appears to be part of an adaptive cellular response to oxidative and inflammatory stress, possibly mediating effects that help preserve cellular homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luigi Chiricosta, Agnese Gugliandolo, Francesca Diomede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Moringin Pretreatment Inhibits the Expression of Genes Involved in Mitophagy in the Stem Cell of the Human Periodontal Ligament."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules24183217"}], "href": "https://doi.org/10.3390/molecules24183217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31487916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31487916"}]}]}]}
Synonyms FAM243A, C21orf140
Proteins CU140_HUMAN
NCBI Gene ID 101928147
API
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Predicted Functions View C21ORF140's ARCHS4 Predicted Functions.
Co-expressed Genes View C21ORF140's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View C21ORF140's ARCHS4 Predicted Functions.

Functional Associations

C21ORF140 has 283 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for C21ORF140 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of C21ORF140 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of C21ORF140 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with C21ORF140 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by C21ORF140 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of C21ORF140 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of C21ORF140 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of C21ORF140 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of C21ORF140 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of C21ORF140 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of C21ORF140 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of C21ORF140 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of C21ORF140 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of C21ORF140 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with C21ORF140 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.