{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to shed light on the potential biological roles of the uncharacterized gene C22orf42. In a genome‐wide association study of selective immunoglobulin A deficiency (IgAD), C22orf42 was identified among several novel candidate genes, suggesting that genetic variants in this locus may contribute to immune dysregulation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, multi‐omics analysis in acute myelocytic leukemia (AML) incorporated C22orf42 within a prognostic gene signature, indicating that its genomic alterations—whether through copy number variation or other mechanisms—might serve as an independent marker for predicting patient outcomes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In studies of invasive pituitary adenomas, increased promoter methylation accompanied by decreased expression of C22orf42 was observed, implicating epigenetic silencing of this gene in tumor invasion and aggressiveness (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, biochemical characterization has revealed that the protein encoded by C22orf42 undergoes N‐myristoylation—a post‐translational modification known to impact protein trafficking and membrane targeting—thereby suggesting a role in regulating intracellular localization or function (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that C22orf42 may be involved in diverse biological processes, ranging from immune regulation and cancer prognosis to the modulation of protein localization through myristoylation. Further research is warranted to fully elucidate its molecular functions and contributions to disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paola G Bronson, Diana Chang, Tushar Bhangale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3675"}], "href": "https://doi.org/10.1038/ng.3675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27723758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27723758"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haifeng Zhuang, Yu Chen, Xianfu Sheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Searching for a signature involving 10 genes to predict the survival of patients with acute myelocytic leukemia through a combined multi-omics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.9437"}], "href": "https://doi.org/10.7717/peerj.9437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32617195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32617195"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sen Cheng, Weiyan Xie, Yazhou Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-02148-3"}], "href": "https://doi.org/10.1186/s12967-019-02148-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796052"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emi Takamitsu, Motoaki Otsuka, Tatsuki Haebara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Human N-Myristoylated Proteins from Human Complementary DNA Resources by Cell-Free and Cellular Metabolic Labeling Analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0136360"}], "href": "https://doi.org/10.1371/journal.pone.0136360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26308446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26308446"}]}]}]}