C4ORF17 Gene

Name chromosome 4 open reading frame 17
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent study investigating novel components of the canonical Wnt/β‐catenin signaling pathway during early embryogenesis, a gene corresponding to the human C4orf17 was characterized as part of a dual‐function orthologue (Ci‐Spatial/C4orf17) in the ascidian."}, {"type": "i", "children": [{"type": "t", "text": "Ciona intestinalis"}]}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional knockdown of Ci‐Spatial/C4orf17 yielded phenotypes that closely mimicked those observed after β‐catenin depletion. Specifically, reduced expression of known downstream target genes of β‐catenin and subsequent disruptions in endoderm formation were observed. Furthermore, the study demonstrated dosage‐sensitive interactions between Ci‐Spatial/C4orf17 and β‐catenin, implying that C4orf17 acts upstream of or in parallel with β‐catenin to ensure proper signaling during early development. These findings support a role for C4orf17 as a crucial mediator in the embryonic Wnt/β‐catenin signaling cascade, with potential implications for understanding its function in human biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuichi Wada, Mayuko Hamada, Kenji Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel genes involved in canonical Wnt/beta-catenin signaling pathway in early Ciona intestinalis embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Growth Differ (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-169X.2008.01012.x"}], "href": "https://doi.org/10.1111/j.1440-169X.2008.01012.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18336583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18336583"}]}]}]}
Synonyms C4orf17
Proteins CD017_HUMAN
NCBI Gene ID 84103
API
Download Associations
Predicted Functions View C4ORF17's ARCHS4 Predicted Functions.
Co-expressed Genes View C4ORF17's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View C4ORF17's ARCHS4 Predicted Functions.

Functional Associations

C4ORF17 has 1,297 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 43 datasets.

Click the + buttons to view associations for C4ORF17 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of C4ORF17 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of C4ORF17 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of C4ORF17 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of C4ORF17 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of C4ORF17 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of C4ORF17 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of C4ORF17 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of C4ORF17 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of C4ORF17 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by C4ORF17 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with C4ORF17 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with C4ORF17 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with C4ORF17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with C4ORF17 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at C4ORF17 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of C4ORF17 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of C4ORF17 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of C4ORF17 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of C4ORF17 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of C4ORF17 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of C4ORF17 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with C4ORF17 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
GWASdb SNP-Disease Associations diseases associated with C4ORF17 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with C4ORF17 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of C4ORF17 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for C4ORF17 from the curated Hub Proteins Protein-Protein Interactions dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of C4ORF17 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of C4ORF17 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of C4ORF17 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain C4ORF17 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MiRTarBase microRNA Targets microRNAs targeting C4ORF17 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of C4ORF17 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
NURSA Protein Complexes protein complexs containing C4ORF17 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for C4ORF17 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of C4ORF17 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of C4ORF17 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of C4ORF17 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of C4ORF17 gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of C4ORF17 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of C4ORF17 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of C4ORF17 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of C4ORF17 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with C4ORF17 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.