CABIN1 Gene

Name	calcineurin binding protein 1
Description	Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CABIN1 is a multifunctional protein that plays dual, context‐dependent roles in cell signaling and chromatin regulation. On one hand, CABIN1 acts as a transcriptional corepressor – it directly interacts with transcription factors such as MEF2 and p53, thereby modulating gene expression. In T lymphocytes and other cells, CABIN1 (also known as Cain) binds to calcineurin and inhibits its phosphatase activity; under conditions of increased intracellular calcium, calpain‐mediated cleavage of CABIN1 relieves this inhibition to trigger downstream responses such as NFAT activation and, in cardiac myocytes, remodeling events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " Moreover, by recruiting chromatin‐modifying enzymes such as histone deacetylases and methyltransferases (e.g. SUV39H1), CABIN1 participates in repressing target genes regulated by MEF2."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n On the other hand, CABIN1 is also an integral component of the HIRA (or HUCA) histone chaperone complex—a group that includes HIRA, UBN1, and ASF1a—which is responsible for the replication‐independent deposition of the histone variant H3.3 onto chromatin. Through its participation in this complex, CABIN1 contributes to proper chromatin assembly at promoters, enhancers, and other regulatory regions, thereby influencing gene expression programs involved in processes such as cellular senescence, differentiation, viral latency, and even aspects of neural function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to these mechanistic roles, alterations in CABIN1—whether by changes in gene methylation or sequence variation—have been implicated in human disease. Genetic studies have associated the CABIN1 locus with susceptibility to amyotrophic lateral sclerosis, while epigenetic modifications of CABIN1 have been observed in ovarian cancer and meningiomas."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": " Thus, CABIN1 serves as both a key mediator of chromatin deposition and a critical regulator of transcription factor activity, positioning it as an important node in development, stress signaling, and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carol Y Ying, David Dominguez-Sola, Melissa Fabi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2688"}], "href": "https://doi.org/10.1038/ni.2688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23974956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23974956"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aidong Han, Fan Pan, James C Stroud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01555"}], "href": "https://doi.org/10.1038/nature01555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12700764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12700764"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Min-Jung Kim, Dong-Gyu Jo, Gil-Sun Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.152336999"}], "href": "https://doi.org/10.1073/pnas.152336999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12114545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12114545"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyonchol Jang, Doo-Eun Choi, Hyungsoo Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611199200"}], "href": "https://doi.org/10.1074/jbc.M611199200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17172641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17172641"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hyonchol Jang, Soo-Youn Choi, Eun-Jung Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cabin1 restrains p53 activity on chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1657"}], "href": "https://doi.org/10.1038/nsmb.1657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19668210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19668210"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dachun Yang, Shuangtao Ma, Yan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm_00000448"}], "href": "https://doi.org/10.3892/ijmm_00000448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20514436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20514436"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nikolay A Pchelintsev, Tony McBryan, Taranjit Singh Rai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placing the HIRA histone chaperone complex in the chromatin landscape."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2013.03.026"}], "href": "https://doi.org/10.1016/j.celrep.2013.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23602572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23602572"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Daniel Ricketts, Brian Frederick, Henry Hoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8711"}], "href": "https://doi.org/10.1038/ncomms8711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26159857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26159857"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Taranjit Singh Rai, Aastha Puri, Tony McBryan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.05546-11"}], "href": "https://doi.org/10.1128/MCB.05546-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21807893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21807893"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dominique Ray-Gallet, M Daniel Ricketts, Yukari Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05581-y"}], "href": "https://doi.org/10.1038/s41467-018-05581-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30082790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30082790"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Min Deng, Ling Wei, Xianbo Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2627"}], "href": "https://doi.org/10.1038/ng.2627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23624525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23624525"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qinghua Feng, Georgios Deftereos, Stephen E Hawes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA hypermethylation, Her-2/neu overexpression and p53 mutations in ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2008.07.036"}], "href": "https://doi.org/10.1016/j.ygyno.2008.07.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18757082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18757082"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3198-4"}], "href": "https://doi.org/10.1186/s12885-017-3198-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28327132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28327132"}]}]}]}
Synonyms	PPP3IN, KB-318B8.7
Proteins	CABIN_HUMAN
NCBI Gene ID	23523
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CABIN1 has 7,421 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for CABIN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CABIN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CABIN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CABIN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CABIN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CABIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CABIN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CABIN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CABIN1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CABIN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CABIN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CABIN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CABIN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CABIN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CABIN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CABIN1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CABIN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CABIN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CABIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CABIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CABIN1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CABIN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CABIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CABIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CABIN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CABIN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CABIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CABIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CABIN1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CABIN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CABIN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CABIN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CABIN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CABIN1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CABIN1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CABIN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CABIN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CABIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CABIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CABIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CABIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CABIN1 gene from the ENCODE Histone Modification Site Profiles dataset.