{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CARMIL3 is emerging as a multifunctional regulator of actin dynamics with diverse roles in cell migration, signaling, and development. In tumor cells, elevated expression of CARMIL3 promotes migration, invasion, and metastatic colonization, indicating its importance in driving aggressive cancer behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In macrophages, CARMIL3 plays a crucial cell‐intrinsic role by modulating the transcription of key proinflammatory cytokines; its deficiency leads to diminished expression of cytokines such as IL‑6, TNF‑α, IL‑1β, and IL‑23 while enhancing anti‐inflammatory IL‑10 levels, a process that is associated with impaired NF‑κB signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the developing brain, CARMIL3 is localized at nascent excitatory synapses, where it interacts with synaptic cytoskeletal regulators including actin capping protein to facilitate spine structural maturation and AMPA receptor recruitment, which are critical for synapse unsilencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in vivo studies using zebrafish demonstrate that loss of carmil3 impairs endodermal and dorsal forerunner cell migration, disrupts Kupffer’s vesicle formation, and leads to defects in left/right asymmetry, underscoring its essential role in embryonic morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huan Wang, Chao Wang, Guang Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-0722"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-0722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31694931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31694931"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Na Zhao, Wenjuan Dong, Hajeong Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109848"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33246003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33246003"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Erin F Spence, Shataakshi Dube, Akiyoshi Uezu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-08288-w"}], "href": "https://doi.org/10.1038/s41467-019-08288-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30674877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30674877"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Benjamin C Stark, Yuanyuan Gao, Diane S Sepich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2021.09.008"}], "href": "https://doi.org/10.1016/j.ydbio.2021.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34599906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34599906"}]}]}]}