CASR Gene

HGNC Family	G protein-coupled receptors
Name	calcium-sensing receptor
Description	The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The extracellular calcium‐sensing receptor (CaSR) is a versatile, seven‐transmembrane G protein–coupled receptor that functions as a master sensor of extracellular Ca²⁺ and other cations, orchestrating a wide range of physiological processes in diverse tissues. In the immune system, CaSR activation increases intracellular Ca²⁺ and reduces cyclic AMP, thereby promoting the assembly of the NLRP3 inflammasome and the maturation of pro‐inflammatory cytokines, which contributes to the innate immune response ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In hematopoietic tissues, CaSR expressed on stem cells mediates their adhesion and retention within calcium‐rich bone marrow niches, a process that is essential for proper localization of hematopoiesis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "]. In the parathyroid and kidney, CaSR expression—transcriptionally up‐regulated by 1,25‑dihydroxyvitamin D₃ via identified vitamin D response elements—enables fine regulation of serum calcium levels and renal calcium excretion, and its inactivation or altered signaling underlies disorders such as familial hypocalciuric hypercalcemia ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "]. Structural studies of the receptor’s large extracellular domain have revealed the molecular basis for ligand binding, including the role of L‑amino acids and divalent cations as agonists, whereas analysis of extracellular pH effects has shown that proton concentrations further modulate CaSR sensitivity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "]. In epithelial tissues, such as the mammary gland and colon, CaSR demonstrates context‐dependent regulation; in normal mammary epithelial cells, it inhibits secretion of parathyroid hormone–related protein (PTHrP), while in transformed cells it exerts the opposite effect, and in the gut, its activation by certain dipeptides can attenuate pro‐inflammatory signaling ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "]. Furthermore, genetic variation in the CASR gene has been linked to alterations in renal calcium handling and susceptibility to hypercalciuria ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "], while recent evidence also implicates CaSR in governing cellular processes such as constitutive macropinocytosis in immune cells ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "]. Finally, CaSR is expressed in vascular smooth muscle cells where it modulates mitogen‐activated protein kinase pathways and may influence vascular calcification, and biased allosteric modulation of the receptor offers promise for targeted therapeutics ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "]. Together, these findings underscore CaSR’s multifaceted role in calcium homeostasis, immune regulation, tissue-specific hormone secretion, and cellular signaling, highlighting its potential as a therapeutic target in disorders ranging from metabolic bone disease to chronic inflammation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Geun-Shik Lee, Naeha Subramanian, Andrew I Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11588"}], "href": "https://doi.org/10.1038/nature11588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23143333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23143333"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manuela Rossol, Matthias Pierer, Nora Raulien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2339"}], "href": "https://doi.org/10.1038/ncomms2339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23271661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23271661"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gregor B Adams, Karissa T Chabner, Ian R Alley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04247"}], "href": "https://doi.org/10.1038/nature04247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16382241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16382241"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lucie Canaff, Geoffrey N Hendy "}, {"type": "b", "children": [{"type": "t", "text": "Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201804200"}], "href": "https://doi.org/10.1074/jbc.M201804200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12036954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12036954"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Claudine H Kos, Andrew C Karaplis, Ji-Bin Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI17416"}], "href": "https://doi.org/10.1172/JCI17416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12671051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12671051"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ogo I Egbuna, Edward M Brown "}, {"type": "b", "children": [{"type": "t", "text": "Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Best Pract Res Clin Rheumatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.berh.2007.11.006"}], "href": "https://doi.org/10.1016/j.berh.2007.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18328986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18328986"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yong Geng, Lidia Mosyak, Igor Kurinov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural mechanism of ligand activation in human calcium-sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.13662"}], "href": "https://doi.org/10.7554/eLife.13662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27434672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27434672"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Stephen J Quinn, Mei Bai, Edward M Brown "}, {"type": "b", "children": [{"type": "t", "text": "pH Sensing by the calcium-sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404520200"}], "href": "https://doi.org/10.1074/jbc.M404520200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15201280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15201280"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ramanaiah Mamillapalli, Joshua VanHouten, Walter Zawalich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801738200"}], "href": "https://doi.org/10.1074/jbc.M801738200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18621740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18621740"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Joshua VanHouten, Pamela Dann, Grace McGeoch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI18776"}], "href": "https://doi.org/10.1172/JCI18776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966569"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hua Zhang, Jennifer Kovacs-Nolan, Tomohiro Kodera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2014.12.023"}], "href": "https://doi.org/10.1016/j.bbadis.2014.12.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25558818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25558818"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Giuseppe Vezzoli, Annalisa Tanini, Luigi Ferrucci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.asn.0000030077.72157.d2"}], "href": "https://doi.org/10.1097/01.asn.0000030077.72157.d2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12239240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12239240"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Johnathan Canton, Daniel Schlam, Christian Breuer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11284"}], "href": "https://doi.org/10.1038/ncomms11284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27050483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27050483"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Guerman Molostvov, Sean James, Simon Fletcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular calcium-sensing receptor is functionally expressed in human artery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00474.2006"}], "href": "https://doi.org/10.1152/ajprenal.00474.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17537980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17537980"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Anna E Davey, Katie Leach, Celine Valant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2011-1426"}], "href": "https://doi.org/10.1210/en.2011-1426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22210744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22210744"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qisheng Tu, Min Pi, Gerard Karsenty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI17054"}], "href": "https://doi.org/10.1172/JCI17054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12671052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12671052"}]}]}]}
Synonyms	HYPOC1, PCAR1, EIG8, FIH, HHC1, FHH, HHC, NSHPT, CAR, hCasR, GPRC2A
Proteins	CASR_HUMAN
NCBI Gene ID	846
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CASR has 6,825 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for CASR from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CASR Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CASR gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CASR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CASR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CASR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CASR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CASR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CASR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CASR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CASR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CASR gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CASR gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CASR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CASR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with CASR gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CASR gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CASR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CASR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CASR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CASR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CASR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CASR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CASR gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CASR gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CASR gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CASR gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CASR gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CASR gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CASR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CASR gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CASR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CASR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CASR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CASR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CASR protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CASR gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CASR gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CASR gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CASR from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CASR gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CASR gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.