{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the four studies directly investigate CBWD2, its genomic context allows for some informed inferences regarding its potential roles. In a study of high‐risk B‐progenitor acute lymphoblastic leukemia (Ph‐like ALL), disruption of kinase signaling by rearrangements and mutations was shown to drive malignant transformation and sensitivity to targeted inhibitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In separate genome‐wide association analyses examining sleep duration, significant associations were found at loci on chromosome 2—including regions near key thyroid regulatory factors—with implications for neurobehavioral, metabolic, and psychiatric outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, evolutionary genomics research describing the head‐to‐head fusion that produced human chromosome 2 pointed to potential advantages conferred by genomic losses or regulatory modifications at fusion breakpoints, which may include genes located in the affected 2q13 region."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that CBWD2—by virtue of residing in a genetically and regulatory complex region of chromosome 2 that is implicated in both aberrant signal transduction and neurobehavioral traits—may partake in modulating pathways related to kinase signaling and neurophysiological regulation. While its precise biological function remains to be fully characterized, the convergence of data from cancer biology, sleep genetics, and evolutionary genomics emphasizes the potential importance of CBWD2 in diverse physiological and pathological processes. Further functional studies are warranted to directly elucidate its role within these networks.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kathryn G Roberts, Ryan D Morin, Jinghui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2012.06.005"}], "href": "https://doi.org/10.1016/j.ccr.2012.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22897847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22897847"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "D J Gottlieb, K Hek, T-H Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2014.133"}], "href": "https://doi.org/10.1038/mp.2014.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25469926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25469926"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Olivia J Veatch, Brendan T Keenan, Philip R Gehrman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pleiotropic genetic effects influencing sleep and neurological disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lancet Neurol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S1474-4422(16)30339-8"}], "href": "https://doi.org/10.1016/S1474-4422(16"}, {"type": "t", "text": "30339-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28102151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28102151"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Paweł Stankiewicz "}, {"type": "b", "children": [{"type": "t", "text": "One pedigree we all may have come from - did Adam and Eve have the chromosome 2 fusion?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cytogenet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13039-016-0283-3"}], "href": "https://doi.org/10.1186/s13039-016-0283-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27708712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27708712"}]}]}]}