CBY1 Gene

Name	chibby homolog 1 (Drosophila)
Description	Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nChibby1 (CBY1) is an evolutionarily conserved protein that antagonizes canonical Wnt/β‐catenin signaling. Acting as a negative regulator, CBY1 directly binds to the C-terminal region of β‐catenin—competing with Tcf/Lef transcription factors—and promotes nuclear export of β‐catenin via its interaction with 14-3-3 proteins. CBY1 contains distinct nuclear localization and export signals, and structural analyses have revealed that while its N-terminal region is largely unstructured, its C-terminal portion forms a coiled-coil domain instrumental for self-association and binding to regulatory partners such as TC-1. These molecular features collectively enable CBY1 to modulate the intracellular distribution and transcriptional activity of β‐catenin."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in Wnt signaling, CBY1 is pivotal for proper cellular differentiation and ciliogenesis. In adipogenic models, CBY1 is required for differentiation into mature adipocytes, acting in part by suppressing β‐catenin activity. At the subcellular level, CBY1 localizes to centrioles and basal bodies where it facilitates the docking and formation of primary and motile cilia through interactions with proteins such as FAM92 and Cenexin; loss-of-function mutations in CBY1 are associated with Joubert syndrome, a ciliopathy. Moreover, altered expression of CBY1 has been implicated in colorectal tumorigenesis, with studies demonstrating its dysregulation in colon carcinoma cells and its ability to interact with NBPF proteins and TC-1 to influence differentiation processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathologically, reduced CBY1 expression and activity have been linked to enhanced β‐catenin signaling in various cancers. In chronic myeloid leukemia (CML), for example, diminished CBY1—resulting from transcriptional repression, promoter hypermethylation, and decreased protein stability—contributes to the aberrant nuclear accumulation of β‐catenin in leukemic stem cells. Similarly, in solid tumors such as laryngeal and gastric carcinomas, lower CBY1 levels correlate with deregulated β‐catenin signaling and augmented tumor growth, while restoration of CBY1 expression leads to growth inhibition and induction of mesenchymal-to-epithelial transition phenotypes. Moreover, in breast cancer stem cells, regulatory long noncoding RNAs target the CBY1 promoter to prevent proper formation of the 14-3-3/β‐catenin/CBY1 complex, thereby sustaining nuclear β‐catenin accumulation and stemness features. In contrast, analyses of common genetic variants in CBY1 suggest that while rare mutations exist, such variations are not a major determinant of obesity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ken-Ichi Takemaru, Shinji Yamaguchi, Young Sik Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01570"}], "href": "https://doi.org/10.1038/nature01570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12712206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12712206"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng-Qian Li, Adaobi Mofunanya, Kimberley Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200709091"}], "href": "https://doi.org/10.1083/jcb.200709091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18573912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18573912"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feng-Qian Li, Adaobi Mofunanya, Victoria Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0437"}], "href": "https://doi.org/10.1091/mbc.e09-05-0437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19940019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19940019"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sulayman Mokhtarzada, Corey Yu, Anne Brickenden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi101236z"}], "href": "https://doi.org/10.1021/bi101236z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21182262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21182262"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Adaobi Mofunanya, Feng-Qian Li, Jen-Chih Hsieh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2199-10-41"}], "href": "https://doi.org/10.1186/1471-2199-10-41"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19435523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19435523"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ryan C Killoran, Modupeola A Sowole, Mohammad A Halim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.2936"}], "href": "https://doi.org/10.1002/pro.2936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27082063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27082063"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Feng-Qian Li, Amar M Singh, Adaobi Mofunanya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01640-06"}], "href": "https://doi.org/10.1128/MCB.01640-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17403895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17403895"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Feng-Qian Li, Xingwang Chen, Cody Fisher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00160-16"}], "href": "https://doi.org/10.1128/MCB.00160-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27528616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27528616"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nathan Steere, Vanessa Chae, Michael Burke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0041077"}], "href": "https://doi.org/10.1371/journal.pone.0041077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22911743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22911743"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Daniel Epting, Lokuliyange D S Senaratne, Elisabeth Ott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.24127"}], "href": "https://doi.org/10.1002/humu.24127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33131181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33131181"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marion M Schuierer, Elisabeth Graf, Ken-Ichi Takemaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v12.i10.1529"}], "href": "https://doi.org/10.3748/wjg.v12.i10.1529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16570344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16570344"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sophie Gad, David Teboul, Astrid Lièvre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-4-31"}], "href": "https://doi.org/10.1186/1471-2407-4-31"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15245581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15245581"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Karl Vandepoele, Katrien Staes, Vanessa Andries, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.01.019"}], "href": "https://doi.org/10.1016/j.yexcr.2010.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20096688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20096688"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chris Gall, Hanyu Xu, Anne Brickenden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1110/ps.073062707"}], "href": "https://doi.org/10.1110/ps.073062707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17905836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17905836"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Manuela Mancini, Elisa Leo, Ken-Ichi Takemaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2013.05.019"}], "href": "https://doi.org/10.1016/j.cellsig.2013.05.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23707389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23707389"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elisa Leo, Manuela Mancini, Michela Aluigi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0081425"}], "href": "https://doi.org/10.1371/journal.pone.0081425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24339928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24339928"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Manuela Mancini, Elisa Leo, Ken-Ichi Takemaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0131074"}], "href": "https://doi.org/10.1371/journal.pone.0131074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26147002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26147002"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Elisa Leo, Manuela Mancini, Fausto Castagnetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.25010"}], "href": "https://doi.org/10.1002/jcb.25010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25389112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25389112"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Victoria Fischer, Michael Wong, Feng-Qian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1281478"}], "href": "https://doi.org/10.1080/15384101.2017.1281478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28107095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28107095"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jue Xu, Gang Ren, De-An Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3451"}], "href": "https://doi.org/10.3892/or.2014.3451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25175341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25175341"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Feng-Qian Li, Luis Chiriboga, Margaret A Black, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chibby is a weak regulator of β-catenin activity in gastric epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27062"}], "href": "https://doi.org/10.1002/jcp.27062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30063079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30063079"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Siyang Wen, Yilu Qin, Rui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03708-6"}], "href": "https://doi.org/10.1038/s41419-021-03708-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33934099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33934099"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jasmijn K Van Camp, Doreen Zegers, Stijn L Verhulst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No important role for genetic variation in the Chibby gene in monogenic and complex obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-013-2541-3"}], "href": "https://doi.org/10.1007/s11033-013-2541-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23645032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23645032"}]}]}]}
Synonyms	HS508I15A, C22ORF2, PGEA1, Chibby1, PIGEA-14, PIGEA14, CBY
Proteins	CBY1_HUMAN
NCBI Gene ID	25776
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CBY1 has 5,509 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for CBY1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CBY1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CBY1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CBY1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CBY1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CBY1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CBY1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CBY1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CBY1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CBY1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CBY1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CBY1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CBY1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CBY1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CBY1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CBY1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CBY1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CBY1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CBY1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CBY1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CBY1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CBY1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CBY1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CBY1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CBY1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CBY1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CBY1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CBY1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CBY1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CBY1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CBY1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CBY1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CBY1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CBY1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CBY1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CBY1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CBY1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CBY1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CBY1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CBY1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CBY1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CBY1 from the GeneSigDB Published Gene Signatures dataset.