{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CC2D1B is an evolutionarily conserved protein that plays a pivotal role in regulating membrane remodeling events through its interactions with the ESCRT‐III machinery. As a member of the Lgd (lethal (2) giant discs) protein family, CC2D1B harbors several conserved DM14 domains that mediate high‐affinity interactions with core ESCRT components, particularly CHMP4B. These interactions enable CC2D1B to modulate ESCRT‐III polymerization by effectively “licensing” the assembly of ESCRT‐III polymers. In doing so, CC2D1B contributes to multiple cellular processes, including proper nuclear envelope reformation during mitotic exit by coordinating the deposition of endoplasmic reticulum membranes around chromatin and guiding the spatiotemporal recruitment of the CHMP7–ESCRT‐III axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of endosomal trafficking, CC2D1B (in cooperation with its paralog CC2D1A) regulates the sorting of membrane receptors by interacting directly with CHMP4 proteins. This interaction prevents premature ESCRT‐III polymerization and thereby delays the sorting of receptors such as EGFR and TLR4 into intraluminal vesicles, ultimately modulating the degradation kinetics and downstream signaling of these receptors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in membrane remodeling, CC2D1B has been linked to additional cellular functions. It shares structural features with Freud‐1 (CC2D1A), a transcriptional repressor, hinting at potential, albeit less characterized, roles in gene regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Although mouse models lacking CC2D1B exhibit no overt phenotype, studies in humans have implicated mutations in CC2D1B in spermatogenesis defects—specifically abnormal sperm head formation—indicating a possible role in reproductive biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the multifunctional nature of CC2D1B. By orchestrating ESCRT‐III assembly at key cellular sites, it ensures proper nuclear envelope reformation, regulates receptor trafficking and degradation, and may even contribute to aspects of gene regulation and reproductive development. Such multifaceted roles are central to the maintenance of cellular homeostasis and proper developmental outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leandro N Ventimiglia, Miguel Angel Cuesta-Geijo, Nicolas Martinelli, et al. 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