{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A careful review of the provided abstracts shows that none of the studies explicitly characterize the function of the gene CCDC153. In most cases the reported transcriptome and genome‐wide analyses describe differential gene expression or candidate genes involved in diverse physiological processes such as ethanol consumption and exercise‐induced changes (for example"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", hypothalamic control of energy balance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", thermal stress responses in muscle"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and mechanisms underlying epileptogenesis after febrile seizures"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", among others"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ", and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, the study investigating the genetic basis of chicken tail feather color identified a genomic region on chromosome 24 that contains nine known genes. Although the abstract is truncated and does not list all candidate genes explicitly, it is possible that CCDC153 is among these candidates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " If so, its inclusion in this region implies a potential role in mediating phenotypic variation related to feather pigmentation. However, no functional evidence or mechanistic insights regarding CCDC153 were provided in that work.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while there is an indication from one genome‐wide association study that CCDC153 (a “coiled‐coil domain containing” gene) may be linked to a specific pigmentation phenotype in chickens, its biological function remains largely uncharacterized in these abstracts. Further dedicated studies will be required to elucidate the molecular role of CCDC153.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T M Darlington, R D McCarthy, R J Cox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gbb.12294"}], "href": "https://doi.org/10.1111/gbb.12294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27063791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27063791"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John N Campbell, Evan Z Macosko, Henning Fenselau, et al. 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