{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have identified the coiled‐coil domain containing 177 (CCDC177) gene as a potential prognostic biomarker in several disease contexts. In lung squamous cell carcinoma, for example, multivariate analyses revealed that among a panel of transcripts, CCDC177—as part of a three‐gene signature including KLK6 and SLITRK5—is significantly associated with overall survival, suggesting that its differential expression may reflect meaningful perturbations in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, analyses of interstitial deletions at chromosome band 14q24.1–q24.3, which encompass a cluster of 19 genes, have implicated haploinsufficiency of CCDC177 along with neighboring genes in congenital anomalies such as various cardiac defects and dysmorphic features; this observation implies that reduced dosage of CCDC177 may contribute to developmental phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a separate investigation focused on neuroblastoma, differential methylation assays that included a region within CCDC177 were among those demonstrating prognostic value for event‐free survival, further supporting the gene’s potential utility as a molecular marker in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the precise biological function of CCDC177 remains to be fully elucidated, its repeated emergence as part of prognostic gene signatures in both epithelial tumors and pediatric cancers—as well as its involvement in chromosomal deletion syndromes—suggests that it may play a regulatory or structural role that impacts tumor progression and developmental processes. Ongoing functional studies are needed to determine whether CCDC177 has a direct role in cell–cell adhesion, signal transduction, or other pathways that could modulate oncogenic behavior and organogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiang Ju, Yan-Jie Zhao, Sai Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of prognostic-related lncRNAs, miRNAs and mRNAs forming a competing endogenous RNA network in lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-020-03224-8"}], "href": "https://doi.org/10.1007/s00432-020-03224-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32356177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32356177"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Barbara Oehl-Jaschkowitz, Olivier M Vanakker, Anne De Paepe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletions in 14q24.1q24.3 are associated with congenital heart defects, brachydactyly, and mild intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36321"}], "href": "https://doi.org/10.1002/ajmg.a.36321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24357125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24357125"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anneleen Decock, Maté Ongenaert, Robrecht Cannoodt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6477"}], "href": "https://doi.org/10.18632/oncotarget.6477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26646589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26646589"}]}]}]}