{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts comprehensively explore the regulatory activities of microRNA‐761 in diverse cellular contexts – including mitochondrial fission leading to cardiomyocyte apoptosis (via the mitochondrial fission factor, MFF) and exercise‐induced alterations in mitochondrial biogenesis through modulation of PGC‑1α – none of these studies mention or address any function for CCDC187. The study examining cardiomyocyte responses to oxidative stress and ischemia/reperfusion injury showed that miR‐761 directly targets MFF, thereby inhibiting mitochondrial fission and reducing cell apoptosis, and thus suggests that post‐transcriptional regulation via microRNAs can critically influence cell fate under stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAnother set of investigations focused on skeletal muscle adaptations and nasal mucosa remodeling demonstrates that miR‐761 can downregulate mitochondrial biogenesis by targeting the 3′‑UTR of PGC‑1α, as well as influence fibroblast activation in the context of radiation‑induced pulmonary fibrosis. These studies collectively highlight the importance of miR‑761–mediated pathways in modulating mitochondrial dynamics, epithelial‑mesenchymal transition and fibrotic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further investigation into radiation‑induced pulmonary fibrosis reinforced that inhibition of miR‑761 can restore PGC‑1α expression, thereby attenuating fibroblast activation and mitigating lung fibrosis. Though miR‑761 and its downstream targets (MFF and PGC‑1α) are well‐characterized in these contexts, there is no indication from any of these abstracts that the coiled‑coil domain containing 187 (CCDC187) is implicated in these or related pathways. Thus, while these studies robustly detail miR‑761–mediated regulation of mitochondrial dynamics and fibrotic processes, they provide no evidence for a functional role of CCDC187."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bo Long, Kun Wang, Na Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2013.07.009"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2013.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23867156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23867156"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanli Xu, Chaoxian Zhao, Xuewen Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-761 regulates mitochondrial biogenesis in mouse skeletal muscle in response to exercise."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.09.113"}], "href": "https://doi.org/10.1016/j.bbrc.2015.09.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26408907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26408907"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinzhang Cheng, Junjun Chen, Yin Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-761 suppresses remodeling of nasal mucosa and epithelial-mesenchymal transition in mice with chronic rhinosinusitis through LCN2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-020-01598-7"}], "href": "https://doi.org/10.1186/s13287-020-01598-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32272958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32272958"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zeng Wang, Junying Chen, Li Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-761 ameliorates radiation-induced pulmonary fibrosis by regulating PGC-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Lung Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01902148.2022.2104407"}], "href": "https://doi.org/10.1080/01902148.2022.2104407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35903964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35903964"}]}]}]}