CCDC25 Gene

Name	coiled-coil domain containing 25
Description	Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies reveal that the coiled‐coil domain containing protein 25 (CCDC25) plays multifaceted roles in disease processes. In cancer, CCDC25 functions as a receptor that mediates the pro‐metastatic effects of extracellular traps: neutrophil extracellular traps (NETs) not only trap pathogens but also, when present in the tumor microenvironment, act as chemotactic cues for circulating tumor cells. CCDC25 binds NET‐associated components, thereby promoting tumor cell recruitment, vascular permeability, and the reawakening of dormant cells, which ultimately contributes to metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cholangiocarcinoma, elevated levels of CCDC25 have been detected in both tumor tissues and patients’ sera. Its secretion via a non‐conventional pathway and interactions with binding proteins such as kallikrein‐11 not only suggest a role in tumor biology but also indicate its potential utility as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of inflammatory diseases, particularly allergic asthma, CCDC25 is part of a signaling cascade—namely the CCDC25–ILK–PKCα–CRTC1 pathway—that is activated by extracellular traps released by eosinophils. This pathway leads to the activation of pulmonary neuroendocrine cells and the amplification of allergic immune responses; notably, inhibition of CCDC25 ameliorates allergic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies have found that variants in CCDC25 associate with plasma enzyme activities relevant to neuropsychiatric disorders such as schizophrenia, and altered expression of CCDC25 may contribute to resistance mechanisms in multiple myeloma, underscoring its involvement in a spectrum of pathological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meghan L De Meo, Jonathan D Spicer "}, {"type": "b", "children": [{"type": "t", "text": "The role of neutrophil extracellular traps in cancer progression and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Semin Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.smim.2022.101595"}], "href": "https://doi.org/10.1016/j.smim.2022.101595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35125298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35125298"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yulin Wan, Xiaoqian Ma, Yin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Local strong acids: A driving force for metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Hypotheses (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mehy.2020.110221"}], "href": "https://doi.org/10.1016/j.mehy.2020.110221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33254528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33254528"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Saeranee Siriphak, Ravinnipa Chanakankun, Tanakorn Proungvitaya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules26113105"}], "href": "https://doi.org/10.3390/molecules26113105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34067437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34067437"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ravinnipa Chanakankun, Tanakorn Proungvitaya, Daraporn Chua-On, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum coiled-coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.11162"}], "href": "https://doi.org/10.3892/ol.2019.11162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31897206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31897206"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yiwen Lu, Yijiao Huang, Jiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eosinophil extracellular traps drive asthma progression through neuro-immune signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-021-00762-2"}], "href": "https://doi.org/10.1038/s41556-021-00762-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34616019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34616019"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ary Gadelha, Jonathan Coleman, Gerome Breen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.schres.2016.01.043"}], "href": "https://doi.org/10.1016/j.schres.2016.01.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26851141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26851141"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Adil Doganay Duru, Tolga Sutlu, Ann Wallblom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0138248"}], "href": "https://doi.org/10.1371/journal.pone.0138248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26378933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26378933"}]}]}]}
Proteins	CCD25_HUMAN
NCBI Gene ID	55246
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCDC25 has 5,307 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for CCDC25 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCDC25 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC25 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC25 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCDC25 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCDC25 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCDC25 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC25 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC25 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCDC25 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCDC25 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC25 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CCDC25 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CCDC25 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC25 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCDC25 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCDC25 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CCDC25 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCDC25 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCDC25 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCDC25 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CCDC25 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCDC25 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCDC25 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCDC25 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CCDC25 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CCDC25 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CCDC25 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CCDC25 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CCDC25 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCDC25 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCDC25 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCDC25 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCDC25 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCDC25 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC25 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCDC25 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCDC25 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CCDC25 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC25 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CCDC25 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CCDC25 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.