CCDC80 Gene

Name	coiled-coil domain containing 80
Description	Predicted to enable fibronectin binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region; interstitial matrix; and membrane. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCDC80, also known as DRO1 or CL2, is a secreted protein that functions as a multifaceted regulator in diverse tissues. In steroidogenic and adrenocortical cells, CCDC80 is induced as a downstream target of Wnt/β‐catenin signaling and can partially recapitulate the hormone‐suppressing effects of β‐catenin activation independent of steroidogenic factor 1 (NF5a1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In adipose tissue, where CCDC80 is highly expressed, it participates in controlling adipocyte differentiation and energy homeostasis by modulating Wnt/β‐catenin–mediated transcriptional activity; both its downregulation and overexpression can inhibit proper adipocyte maturation, suggesting a finely balanced, dual regulatory role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In cancer models, multiple studies have established a tumor‐suppressive function for CCDC80. In thyroid carcinomas, its markedly reduced expression correlates with loss of E‐cadherin and increased malignancy, while in colorectal and ovarian cancers, loss or repression of CCDC80 is associated with enhanced tumor growth, increased ERK1/2 phosphorylation, and a more aggressive disease phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": " In pancreatic cancer, induction of CCDC80 by TGF‑β signaling inhibition contributes to reduced migration, diminished colony formation, and lower levels of epithelial‐to‐mesenchymal transition markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, in the colon, CCDC80 is identified as a direct transcriptional target of YAP/TAZ whose upregulation is required for the growth‐inhibitory effects observed following LATS1/2 deletion, underscoring its context‐dependent role in modulating cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, in the vascular system, CCDC80 overexpression decreases the expression and activity of lipoprotein lipase via ERK1/2 and TET2 pathways, thereby contributing to elevated plasma lipid levels and accelerated atherosclerosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and its repression by oncogenic factors such as AIB1 further links CCDC80 to apoptotic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these studies indicate that CCDC80 is a critical secreted regulator that links extracellular signaling with differentiation, metabolism, and tumor suppression across multiple biological systems (1,2,3,4,5,6,7,8,10,11,12,13).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elisabeth M Walczak, Rork Kuick, Isabella Finco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2014-1060"}], "href": "https://doi.org/10.1210/me.2014-1060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25029241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25029241"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Frédéric Tremblay, Tracy Revett, Christine Huard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M809535200"}], "href": "https://doi.org/10.1074/jbc.M809535200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19141617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19141617"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Frédéric Tremblay, Christine Huard, Jessie Dow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2012-1242"}], "href": "https://doi.org/10.1210/en.2012-1242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22753645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22753645"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Angelo Ferraro, Filippo Schepis, Vincenza Leone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2012-2926"}], "href": "https://doi.org/10.1210/jc.2012-2926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23666966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23666966"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jessica I Grill, Jens Neumann, Andreas Herbst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-14-0205-T"}], "href": "https://doi.org/10.1158/1541-7786.MCR-14-0205-T"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25053805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25053805"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vincenza Leone, Angelo Ferraro, Filippo Schepis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.12.010"}], "href": "https://doi.org/10.1016/j.canlet.2014.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25497869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25497869"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zi-Qian Liang, Li Gao, Jun-Hong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of the Coiled-Coil Domain Containing 80 and Its Perspective Mechanisms in Ovarian Carcinoma: A Comprehensive Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/3752871"}], "href": "https://doi.org/10.1155/2021/3752871"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34820451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34820451"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eunji Hong, Sujin Park, Akira Ooshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59893-5"}], "href": "https://doi.org/10.1038/s41598-020-59893-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32076068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32076068"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wei-Wei Pan, Toshiro Moroishi, Ja Hyun Koo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell type-dependent function of LATS1/2 in cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0610-8"}], "href": "https://doi.org/10.1038/s41388-018-0610-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30531839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30531839"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jessica I Grill, Jens Neumann, Andrea Ofner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgy077"}], "href": "https://doi.org/10.1093/carcin/bgy077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29901779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29901779"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Duo Gong, Qiang Zhang, Ling-Yan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2018.11.009"}], "href": "https://doi.org/10.1016/j.ejphar.2018.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30439364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30439364"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Juan Ferragud, Alvaro Avivar-Valderas, Antoni Pla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional repression of the tumor suppressor DRO1 by AIB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.08.025"}], "href": "https://doi.org/10.1016/j.febslet.2011.08.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21871888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21871888"}]}]}]}
Synonyms	OKURIBIN, URB, DRO1, SSG1
Proteins	CCD80_HUMAN
NCBI Gene ID	151887
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCDC80 has 7,258 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for CCDC80 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCDC80 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC80 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC80 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCDC80 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCDC80 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCDC80 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC80 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCDC80 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCDC80 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCDC80 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC80 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CCDC80 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC80 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCDC80 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCDC80 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CCDC80 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCDC80 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCDC80 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCDC80 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCDC80 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCDC80 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCDC80 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CCDC80 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CCDC80 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CCDC80 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CCDC80 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CCDC80 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCDC80 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCDC80 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCDC80 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCDC80 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCDC80 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC80 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCDC80 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCDC80 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CCDC80 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CCDC80 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CCDC80 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CCDC80 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of CCDC80 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCDC80 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.