CCNL1 Gene

HGNC Family	Cyclins (CCN)
Name	cyclin L1
Description	Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of RNA splicing. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cyclin L1 (CCNL1) is a member of the cyclin family that plays multifaceted roles in both normal cellular functions and cancer. At the molecular level, CCNL1 participates in the regulation of pre‐mRNA splicing by forming complexes with cyclin‐dependent kinases such as CDK11 and CDK12; its localization to nuclear speckles via an arginine–serine–rich (RS) domain is critical for modulating alternative splicing events (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, genetic studies indicate that sequence variants near the CCNL1 locus can influence developmental traits such as birth weight, underscoring its broader physiological importance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In several cancers—including head and neck squamous cell carcinoma, breast cancer, cervical carcinoma, and prostate cancer—CCNL1 is frequently amplified or overexpressed. In head and neck cancers, copy number gains of CCNL1 correlate with lymph node metastases and reduced overall survival"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in cervical carcinoma CCNL1 amplification is associated with early invasiveness and radio‐resistance, marking it as a potential prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In breast cancer, the interplay between CCNL1 and tissue inhibitors of metalloproteinases appears to intricately modulate cell proliferation, suggesting an involvement in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in prostate cancer, CCNL1 is directly targeted by the tumor‐suppressive miR-5195-3p; downregulation of CCNL1 by this microRNA reduces cell proliferation and impairs cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies reveal that CCNL1 is not only a key regulator of RNA processing via its role in splicing but also an important oncogenic driver whose genetic and expression alterations contribute to tumor aggressiveness and poor clinical outcome. This dual function in normal physiology and in the pathogenesis of several cancers highlights CCNL1 as a promising candidate for both biomarker development and targeted therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pascal Loyer, Janeen H Trembley, Jose A Grenet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708188200"}], "href": "https://doi.org/10.1074/jbc.M708188200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18216018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18216018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hung-Hsi Chen, Yu-Chiuan Wang, Ming-Ji Fann "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.7.2736-2745.2006"}], "href": "https://doi.org/10.1128/MCB.26.7.2736-2745.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537916"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rachel M Freathy, Dennis O Mook-Kanamori, Ulla Sovio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.567"}], "href": "https://doi.org/10.1038/ng.567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20372150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20372150"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Sticht, C Hofele, C Flechtenmacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6602400"}], "href": "https://doi.org/10.1038/sj.bjc.6602400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15700036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15700036"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D Muller, R Millon, S Théobald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603036"}], "href": "https://doi.org/10.1038/sj.bjc.6603036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16598186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16598186"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sraboni Mitra, Dipanjana Mazumder Indra, Partha S Basu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of CyclinL1 in uterine cervical carcinoma has prognostic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.20671"}], "href": "https://doi.org/10.1002/mc.20671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20721974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20721974"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li Peng, Ma Yanjiao, Wang Ai-guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A fine balance between CCNL1 and TIMP1 contributes to the development of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.05.021"}], "href": "https://doi.org/10.1016/j.bbrc.2011.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21586274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21586274"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xing Zeng, Zhiquan Hu, Yuanqing Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5195-3p functions as a tumor suppressor in prostate cancer via targeting CCNL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-022-00326-8"}], "href": "https://doi.org/10.1186/s11658-022-00326-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35260070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35260070"}]}]}]}
Synonyms	ANIA-6A, BM-001, PRO1073, ANIA6A
Proteins	CCNL1_HUMAN
NCBI Gene ID	57018
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCNL1 has 10,653 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for CCNL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCNL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CCNL1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCNL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCNL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCNL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCNL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCNL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCNL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCNL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCNL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCNL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCNL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CCNL1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCNL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCNL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCNL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CCNL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CCNL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCNL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCNL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCNL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCNL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CCNL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CCNL1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CCNL1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CCNL1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CCNL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CCNL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCNL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCNL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCNL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCNL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCNL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCNL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCNL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CCNL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CCNL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CCNL1 from the GeneSigDB Published Gene Signatures dataset.