CCNT2 Gene

HGNC Family	Cyclins (CCN)
Name	cyclin T2
Description	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cyclin T2 (CCNT2) is a regulatory subunit of the positive transcription elongation factor b (P‐TEFb) complex; in association with Cdk9, it phosphorylates the carboxy‐terminal domain of RNA polymerase II to facilitate transcriptional elongation and the release of promoter‐proximal pausing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition to its core role in transcription, CCNT2 has been implicated in regulating cell cycle progression and differentiation. For instance, during myogenesis CCNT2a enhances MyoD‐dependent transcription and cooperates with Cdk9 to phosphorylate proteins such as pRb, thereby promoting muscle differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, CCNT2 expression is subject to regulation by multiple microRNAs that modulate differentiation and proliferation in diverse cell types. In hematopoietic cells, miR‑29a and miR‑142‑3p directly target the CCNT2 gene to promote monocytic and granulocytic differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in acute myeloid leukemia miR‑192 suppresses CCNT2 expression, leading to cell cycle arrest."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in premeiotic germ cells and during muscle differentiation, miR‑15a targets CCNT2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and in osteosarcoma as well as gastric cancer, miR‑188‑5p and miR‑216b, respectively, downregulate CCNT2 contributing to growth suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In a distinct context, studies in vascular cells have uncovered opposing roles of P‐TEFb complexes, as deletion of cyclin T2 (in contrast to cyclin T1) augments stress‐responsive CHOP expression and mineralization, suggesting that CCNT2 normally helps restrain detrimental stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings indicate that CCNT2 plays multifaceted roles in transcription regulation, cell cycle control, and differentiation, with its expression and activity finely tuned by microRNAs and interacting partners.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takeshi Kurosu, Fan Zhang, B Matija Peterlin "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2004.08.027"}], "href": "https://doi.org/10.1016/j.gene.2004.08.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15563843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15563843"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Matthieu Giraud, Nada Jmari, Lina Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1323535111"}], "href": "https://doi.org/10.1073/pnas.1323535111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24434558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24434558"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cristiano Simone, Peter Stiegler, Luigi Bagella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of MyoD-dependent transcription by cdk9/cyclin T2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205493"}], "href": "https://doi.org/10.1038/sj.onc.1205493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12037670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12037670"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cristiano Simone, Luigi Bagella, Cristiana Bellan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Physical interaction between pRb and cdk9/cyclinT2 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205511"}], "href": "https://doi.org/10.1038/sj.onc.1205511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12037672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12037672"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiao-Shuang Wang, Jia-Nan Gong, Jia Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-385716"}], "href": "https://doi.org/10.1182/blood-2011-10-385716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22493297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22493297"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shun Ke, Rui-Chao Li, Jun Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Hematol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12185-017-2232-2"}], "href": "https://doi.org/10.1007/s12185-017-2232-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28409330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28409330"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Teng, Yong Wang, Jun Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin T2: a novel miR-15a target gene involved in early spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.06.031"}], "href": "https://doi.org/10.1016/j.febslet.2011.06.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21740905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21740905"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "F Wang, Q-H Zhao, J-Z Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-188-5p alleviates the progression of osteosarcoma via target degrading CCNT2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_19892"}], "href": "https://doi.org/10.26355/eurrev_202001_19892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31957815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31957815"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xi Chen, Lei Zhang, Qingjie Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000000915"}], "href": "https://doi.org/10.1097/CAD.0000000000000915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32058347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32058347"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yuji Shiozaki, Kayo Okamura, Shohei Kohno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.004706"}], "href": "https://doi.org/10.1074/jbc.RA118.004706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30209133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30209133"}]}]}]}
Synonyms	CYCT2
Proteins	CCNT2_HUMAN
NCBI Gene ID	905
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCNT2 has 6,596 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for CCNT2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCNT2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CCNT2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNT2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNT2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCNT2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCNT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCNT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCNT2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCNT2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCNT2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CCNT2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCNT2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCNT2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CCNT2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCNT2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCNT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCNT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CCNT2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCNT2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCNT2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCNT2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CCNT2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CCNT2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCNT2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCNT2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CCNT2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCNT2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCNT2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CCNT2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CCNT2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CCNT2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCNT2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCNT2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCNT2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCNT2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCNT2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCNT2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCNT2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCNT2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CCNT2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CCNT2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.