{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CP110 is a multifunctional centrosomal protein that plays pivotal roles in regulating both centriole duplication and ciliogenesis. Studies have demonstrated that CP110 acts as a cap at the distal ends of centrioles, where it cooperates with key regulators such as PLK4, Cdk2, HsSAS6, and CPAP to ensure the proper reproduction and controlled elongation of centrioles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In addition, CP110 interacts with partners such as Cep97 and is subject to precise cell cycle–dependent regulation through post‐translational modifications including CDK‐mediated phosphorylation and ubiquitin–dependent degradation via Cyclin F, which together ensure timely removal of the CP110 “cap” to permit the onset of ciliogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " Interestingly, while in cultured cells CP110 has been characterized primarily as a suppressor of primary cilia formation, in vivo findings indicate that CP110 is also required for the proper anchoring of basal bodies to the membrane, contributing to subdistal appendage assembly and facilitating normal ciliogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, deregulation of CP110—whether through sustained overexpression due to inflammatory signals or impaired interactions with binding partners such as calmodulin and centrin—leads to defects in centrosome duplication, resulting in cytokinesis failures and chromosomal instability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the complex, context-dependent functions of CP110 as a molecular switch that integrates centriole assembly and cilia formation with cell cycle progression, with significant implications for maintaining genomic stability and normal developmental processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Robert Habedanck, York-Dieter Stierhof, Christopher J Wilkinson, et al. 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