{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Chaperonin‐containing TCP1 subunit 6A (CCT6A) is a component of the cytosolic TRiC complex that plays diverse roles in protein folding, cytoskeletal organization, and signal transduction. In cancer cells, CCT6A overexpression has been linked to aggressive tumor behavior. For instance, in non‐small cell lung carcinoma CCT6A suppresses SMAD2 function, thereby promoting metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In several tumor types—including cervical cancer, hepatocellular carcinoma, astrocytoma, Ewing sarcoma, and gastric cancer—elevated levels of CCT6A correlate with advanced disease stage, lymph node metastasis, and poorer survival outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": " In glioma, CCT6A is upregulated and functions within a regulatory axis modulated by long non‐coding RNA NEAT1 and miR‑152‑3p to enhance cell viability, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, in colon cancer stem cells, direct targeting of CCT6A by the miR‑148a/152 cluster suppresses malignant features such as proliferation, invasion, and self‑renewal."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Additional studies have implicated CCT6A in neuronal development, where it, along with MAP kinase signaling, contributes to neurite outgrowth and neuronal migration in the developing cerebellum."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Beyond cancer and neurobiology, CCT6A has been identified as a novel autoantigen recognized by Vδ2 γδ T cells in autoimmune conditions, with its increased plasma levels noted in systemic lupus erythematosus and rheumatoid arthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Structural and genetic studies further highlight that as a subunit of the TRiC machinery, CCT6A facilitates ATP‐driven protein folding and that its genetic variants may influence patient survival in certain malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhe Ying, Han Tian, Yun Li, et al. 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