CD300A Gene

HGNC Family	CD molecules (CD), Immunoglobulin superfamily domain containing
Name	CD300a molecule
Description	This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CD300a is an immunoreceptor that contains immunoreceptor tyrosine‐based inhibitory motifs (ITIMs) and is broadly expressed on multiple immune cell types, including natural killer (NK) cells, mast cells, macrophages, dendritic cells, and B cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " It recognizes conserved phospholipid ligands such as phosphatidylserine (PS) and phosphatidylethanolamine (PE) that become exposed on the membrane of apoptotic cells or are associated with viral particles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Engagement of CD300a leads to the recruitment of inhibitory phosphatases (e.g., SHP‐1 via critical ITIM tyrosine residues) and thereby down‐modulates activation signals; for example, in mast cells it suppresses LPS-induced cytokine and chemokine production"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in macrophages it attenuates Toll-like receptor (TLR)–mediated pro-inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In NK cells, CD300a expression varies between clones and its ligation by PS or other ligands expressed on tumor cells can deliver inhibitory signals that restrict cytotoxicity, suggesting that tumor cells may exploit the receptor as an immune evasion mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the context of B lymphocytes, CD300a acts as a negative regulator of B-cell receptor (BCR)–mediated signaling and cellular proliferation, thereby contributing to the fine-tuning of B-cell activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, engagement of CD300a on dendritic cells during inflammatory responses—such as those observed after alum-adjuvanted immunization—can modulate downstream T-cell responses and allergic inflammation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while in plasmacytoid dendritic cells its regulated expression influences the balance of type I interferon and tumor necrosis factor-α production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, in activated CD4⁺ T cells, increased expression of CD300a appears to mark a subset of polyfunctional Th1 cells, suggesting additional roles in shaping adaptive immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings demonstrate that CD300a functions as a broad negative regulator of immune cell activation by recognizing lipid ligands, thereby maintaining immune homeostasis; however, this inhibitory mechanism can be subverted by pathogens and tumor cells to dampen host immune responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Venkateswara R Simhadri, John F Andersen, Eric Calvo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-08-372425"}], "href": "https://doi.org/10.1182/blood-2011-08-372425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22302738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22302738"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dikla Lankry, Hrvoje Simic, Yair Klieger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and function of CD300 in NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903347"}], "href": "https://doi.org/10.4049/jimmunol.0903347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20656921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20656921"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rodolfo Silva, Susan Moir, Lela Kardava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-09-310318"}], "href": "https://doi.org/10.1182/blood-2010-09-310318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482706"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xavier Carnec, Laurent Meertens, Ophélie Dejarnac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01849-15"}], "href": "https://doi.org/10.1128/JVI.01849-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26468529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26468529"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Masamichi Shoji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20120096"}], "href": "https://doi.org/10.1084/jem.20120096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22826299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22826299"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Shin-ichiro Honda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.12.025"}], "href": "https://doi.org/10.1016/j.bbrc.2011.12.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22185693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22185693"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eun-Ju Kim, Sang-Min Lee, Kyoungho Suk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2567.2011.03528.x"}], "href": "https://doi.org/10.1111/j.1365-2567.2011.03528.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22043923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22043923"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dikla Lankry, Tihana Lenac Rovis, Stipan Jonjic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201343433"}], "href": "https://doi.org/10.1002/eji.201343433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23640773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23640773"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Haruka Miki, Chigusa Nakahashi-Oda, Takayuki Sumida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant-Induced Th2 Responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1402915"}], "href": "https://doi.org/10.4049/jimmunol.1402915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25911756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25911756"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xinsheng Ju, Martin Zenke, Derek N J Hart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-12-127951"}], "href": "https://doi.org/10.1182/blood-2007-12-127951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18535206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18535206"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sriram Narayanan, Rodolfo Silva, Giovanna Peruzzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0010636"}], "href": "https://doi.org/10.1371/journal.pone.0010636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20498708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20498708"}]}]}]}
Synonyms	CMRF35H, IRC1/IRC2, CMRF35-H, IRC1, IRP60, CLM-8, CMRF-35H, IGSF12, CMRF35-H9, CMRF35H9, IRC2, CMRF-35-H9
Proteins	CLM8_HUMAN
NCBI Gene ID	11314
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CD300A has 5,582 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.

Click the + buttons to view associations for CD300A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CD300A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD300A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD300A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CD300A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CD300A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CD300A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD300A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CD300A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CD300A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CD300A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CD300A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD300A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CD300A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CD300A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD300A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CD300A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CD300A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CD300A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CD300A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CD300A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CD300A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CD300A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD300A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CD300A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CD300A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CD300A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CD300A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CD300A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CD300A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CD300A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CD300A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD300A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CD300A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CD300A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CD300A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CD300A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CD300A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CD300A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CD300A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of CD300A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CD300A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.