{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The CD300LB receptor, also known as LMIR5/CD300b, is an activating immunoglobulin‐like receptor predominantly expressed on myeloid cells such as mast cells, macrophages, and neutrophils."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Association with the ITAM‐bearing adaptor DAP12 (and less so with DAP10) enables CD300LB to transduce activating signals that promote cytokine production, degranulation, cellular adhesion, and other effector responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n CD300LB recognizes a variety of ligands; it binds phosphatidylserine (PS) exposed on the outer leaflet of apoptotic cells and engages endogenous molecules such as TIM1 and TIM4, while also directly interacting with components derived from pathogens (for example, elements of Campylobacter jejuni or cholera toxin subunit B)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Engagement of CD300LB not only contributes to pro‐inflammatory activation—with the release of a soluble form that can amplify LPS‐induced cytokine production via interactions with TLR4"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "—but also facilitates the clearance of apoptotic cells by accumulating at phagocytic cups and promoting PI3K‐Akt signaling–dependent efferocytosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, CD300LB expression is regulated by external factors such as all‐trans retinoic acid and PMA through activation of the MAP kinase (ERK1/2) signaling pathway, suggesting that its expression is tightly controlled during immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, CD300LB functions as a pivotal modulator of innate immune responses by recognizing both self (e.g., apoptotic cells) and microbial ligands, thereby orchestrating inflammatory signaling, phagocytic clearance, and contributions to pathogen‐induced sepsis and autoimmune processes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoshinori Yamanishi, Jiro Kitaura, Kumi Izawa, et al. 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