CD58 Gene

HGNC Family	CD molecules (CD)
Name	CD58 molecule
Description	This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CD58 is a cell‐surface adhesion molecule that primarily interacts with CD2 to mediate critical costimulatory and adhesion signals during immune responses. Genetic studies in multiple sclerosis (MS) have demonstrated that disease‐protective alleles at the CD58 locus are associated with increased gene expression, which, by engaging CD2, can enhance the function of regulatory T cells and modulate autoreactivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, CD58–CD2 interactions contribute to effective T cell activation and cytotoxic responses; for example, CD58 expressed on endothelial cells participates in providing costimulatory signals to resting memory T cells (thereby promoting IL-2 and IFN-γ production) and can substitute for other adhesion receptors in triggering cytolytic degranulation by cytotoxic lymphocytes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Conversely, genetic defects or downregulation of CD58 have been implicated as mechanisms of immune evasion in cancers; loss-of-function mutations in CD58 are observed in diffuse large B cell lymphoma and peripheral T cell lymphomas, while reduced CD58 expression contributes to resistance to immune checkpoint inhibitors in melanoma by impairing tumor recognition by T cells and natural killer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " CD58 is also upregulated on dendritic cells and activated B cells following proinflammatory stimulation—for example, after exposure to HMGB1 or during viral infection—thereby promoting efficient antigen presentation and costimulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, genetic association studies have implicated CD58 risk alleles in susceptibility not only to MS but also to infectious complications such as candidaemia, underscoring its broad role in host defense."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In certain contexts, deregulation of CD58 expression (for instance, as a consequence of altered transcriptional control by factors such as FOXA1) may further influence the balance between inflammatory and tolerogenic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these findings highlight the multifaceted role of CD58 in modulating immune cell adhesion, costimulation, and surveillance, with significant implications for autoimmunity, cancer immune escape, and infectious disease susceptibility.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.396"}], "href": "https://doi.org/10.1038/ng.396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19525955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19525955"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Philip L De Jager, Clare Baecher-Allan, Lisa M Maier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the CD58 locus in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0813310106"}], "href": "https://doi.org/10.1073/pnas.0813310106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19237575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19237575"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melissa M Mazanet, Christopher C W Hughes "}, {"type": "b", "children": [{"type": "t", "text": "B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.7.3581"}], "href": "https://doi.org/10.4049/jimmunol.169.7.3581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12244148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12244148"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nadia Anikeeva, Kristina Somersalo, Tasha N Sims, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0502467102"}], "href": "https://doi.org/10.1073/pnas.0502467102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15851656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15851656"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Judith Leitner, Dietmar Herndler-Brandstetter, Gerhard J Zlabinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1401917"}], "href": "https://doi.org/10.4049/jimmunol.1401917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26041540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26041540"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Madhavi Challa-Malladi, Yen K Lieu, Olivia Califano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2011.11.006"}], "href": "https://doi.org/10.1016/j.ccr.2011.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22137796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22137796"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chris J Frangieh, Johannes C Melms, Pratiksha I Thakore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-021-00779-1"}], "href": "https://doi.org/10.1038/s41588-021-00779-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649592"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Teresa Palomero, Lucile Couronné, Hossein Khiabanian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2873"}], "href": "https://doi.org/10.1038/ng.2873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24413734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24413734"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Davorka Messmer, Huan Yang, Gloria Telusma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.173.1.307"}], "href": "https://doi.org/10.4049/jimmunol.173.1.307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15210788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15210788"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Giovanna Rappocciolo, Paolo Piazza, Craig L Fuller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.0020070"}], "href": "https://doi.org/10.1371/journal.ppat.0020070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16839201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16839201"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanwen Jiang, David Redmond, Kui Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-014-0432-0"}], "href": "https://doi.org/10.1186/s13059-014-0432-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25123191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25123191"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "G M Bernardo, G Bebek, C L Ginther, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXA1 represses the molecular phenotype of basal breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.62"}], "href": "https://doi.org/10.1038/onc.2012.62"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22391567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22391567"}]}]}]}
Synonyms	LFA-3, LFA3, ag3
Proteins	LFA3_HUMAN
NCBI Gene ID	965
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CD58 has 8,062 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for CD58 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CD58 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CD58 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD58 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CD58 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CD58 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD58 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CD58 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CD58 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD58 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CD58 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CD58 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CD58 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD58 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CD58 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CD58 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CD58 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CD58 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CD58 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CD58 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CD58 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD58 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CD58 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CD58 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CD58 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CD58 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CD58 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CD58 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CD58 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CD58 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CD58 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CD58 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CD58 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CD58 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CD58 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CD58 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CD58 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD58 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CD58 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CD58 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CD58 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CD58 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.