{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CD7 is a transmembrane glycoprotein that functions primarily as a lymphoid‐lineage marker and plays several important roles in both normal T cell development and in hematologic malignancies. As an early marker of lymphoid commitment, CD7 is expressed on T and natural killer (NK) cells and is used to identify T/NK progenitors during hematopoietic differentiation – for example, engagement of Notch signaling in CD34⁺ hematopoietic precursors promotes the emergence of CD7⁺ cells (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In malignant contexts, aberrant CD7 expression is of diagnostic and prognostic importance. In acute myeloid leukemia (AML), for instance, CD7 is frequently overexpressed on blasts in subtypes with CEBPA mutations or silencing events and its expression can be inversely correlated with other molecular markers such as IDH2 (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " CD7 immunophenotyping also contributes to the diagnosis of other hematologic disorders such as Langerhans cell histiocytosis and acute promyelocytic leukemia, where its detection assists in distinguishing disease entities and may provide prognostic insight (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " Furthermore, CD7 has emerged as a critical target in immunotherapy against T‐cell malignancies. In the development of CD7‐directed chimeric antigen receptor (CAR) T cells, native CD7 expression on the effector cells creates challenges via fratricide; the disruption of CD7 expression in these cells enables effective expansion and antitumor activity (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, structural studies reveal that although CD7 is a prominent surface glycoprotein on T cells, it is not recognized as a ligand by certain galectins (in contrast to CD3), suggesting that CD7 engages in unique interactions within the T cell receptor signaling complex."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, studies in the context of early B lymphopoiesis have identified progenitor subsets expressing CD7 that may represent transitional stages during lymphoid specification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kohshi Ohishi, Barbara Varnum-Finney, Irwin D Bernstein "}, {"type": "b", "children": [{"type": "t", "text": "Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI16167"}], "href": "https://doi.org/10.1172/JCI16167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Colleen Delaney, Barbara Varnum-Finney, Keisuke Aoyama, et al. 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