CD72 Gene

HGNC Family	CD molecules (CD)
Name	CD72 molecule
Description	Enables transmembrane signaling receptor activity. Involved in negative regulation of B cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CD72 is a key inhibitory coreceptor expressed on B cells that plays a crucial role in fine‐tuning B cell receptor (BCR) signaling and maintaining immunological tolerance. By virtue of its immunoreceptor tyrosine‐based inhibitory motifs, CD72 recruits phosphatases (such as SHP‐1) to dampen BCR‐mediated activation, thereby preventing overactivation and autoimmunity. Engagement of its natural ligand CD100 (also known as Sema4D) disrupts this inhibitory complex, transiently releasing the brakes on B cell activation so that appropriate immune responses can be mounted. Alterations in this CD72–CD100 regulatory circuit have been implicated in disease settings; for instance, diminished CD72 expression in neoplastic B cells contributes to enhanced survival and proliferation in B cell chronic lymphocytic leukemia, and dysregulation of CD72 signaling is associated with the breakdown of peripheral tolerance in autoimmunity. In addition, CD72 participates in the cross‐talk between regulatory B cells (Bregs) and regulatory T cells (Tregs), and its expression may serve as a diagnostic marker in settings such as minimal residual disease in B‐cell precursor acute lymphoblastic leukemia. Collectively, these findings underscore the pivotal role of CD72 in orchestrating inhibitory signals that balance B cell activation and tolerance, making it a promising target for therapeutic intervention in autoimmune and B cell–driven disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01037"}], "href": "https://doi.org/10.1038/nature01037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12374982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12374982"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Silvia Deaglio, Tiziana Vaisitti, Luciana Bergui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-10-3873"}], "href": "https://doi.org/10.1182/blood-2004-10-3873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15613544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15613544"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Atsushi Kumanogoh, Takashi Shikina, Chie Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/intimm/dxh307"}], "href": "https://doi.org/10.1093/intimm/dxh307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16113236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16113236"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elizabeth O Lobo, Zhifang Zhang, John E Shively "}, {"type": "b", "children": [{"type": "t", "text": "Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0109037"}], "href": "https://doi.org/10.1189/jlb.0109037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19454653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19454653"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mingke Zheng, Chen Xing, He Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/08820139.2014.917096"}], "href": "https://doi.org/10.3109/08820139.2014.917096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24950378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24950378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Prashant R Tembhare, Sitaram Ghogale, Nisha Ghatwai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of new markers for minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia: CD73 and CD86 are the most relevant new markers to increase the efficacy of MRD 2016; 00B: 000-000."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytometry B Clin Cytom (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cyto.b.21486"}], "href": "https://doi.org/10.1002/cyto.b.21486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27718302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27718302"}]}]}]}
Synonyms	CD72B, LYB2
Proteins	CD72_HUMAN
NCBI Gene ID	971
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CD72 has 5,247 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for CD72 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CD72 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CD72 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD72 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD72 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CD72 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CD72 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CD72 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CD72 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CD72 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CD72 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CD72 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CD72 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD72 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CD72 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CD72 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD72 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CD72 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CD72 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CD72 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CD72 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CD72 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CD72 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CD72 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CD72 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CD72 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CD72 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CD72 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CD72 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CD72 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CD72 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CD72 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CD72 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CD72 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD72 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CD72 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CD72 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CD72 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CD72 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CD72 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CD72 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CD72 from the GeneSigDB Published Gene Signatures dataset.